Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SMUNN2025_RS08745 Genome accession   NC_013928
Coordinates   1812359..1813081 (-) Length   240 a.a.
NCBI ID   WP_002263984.1    Uniprot ID   A0AAX1K0W7
Organism   Streptococcus mutans NN2025     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1807359..1818081
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS08720 (SmuNN2025_1707) sufU 1807394..1807828 (-) 435 WP_002265826.1 Fe-S cluster assembly sulfur transfer protein SufU -
  SMUNN2025_RS08725 (SmuNN2025_1708) - 1807815..1809044 (-) 1230 WP_002274586.1 cysteine desulfurase -
  SMUNN2025_RS08730 (SmuNN2025_1709) sufD 1809049..1810311 (-) 1263 WP_002283002.1 Fe-S cluster assembly protein SufD -
  SMUNN2025_RS08735 (SmuNN2025_1710) sufC 1810349..1811119 (-) 771 WP_002262747.1 Fe-S cluster assembly ATPase SufC -
  SMUNN2025_RS08740 (SmuNN2025_1711) rgpG 1811193..1812353 (-) 1161 WP_012997949.1 rhamnose-glucose polysaccharide biosynthesis protein RgpB -
  SMUNN2025_RS08745 (SmuNN2025_1712) mecA 1812359..1813081 (-) 723 WP_002263984.1 adaptor protein MecA Regulator
  SMUNN2025_RS08750 (SmuNN2025_1713) - 1813171..1814016 (-) 846 WP_002283000.1 undecaprenyl-diphosphate phosphatase -
  SMUNN2025_RS08755 (SmuNN2025_1714) - 1814074..1815975 (-) 1902 WP_012997951.1 DUF2207 domain-containing protein -
  SMUNN2025_RS08760 (SmuNN2025_1715) - 1816127..1817680 (+) 1554 WP_002266996.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28028.63 Da        Isoelectric Point: 4.2340

>NTDB_id=36616 SMUNN2025_RS08745 WP_002263984.1 1812359..1813081(-) (mecA) [Streptococcus mutans NN2025]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEI
NKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPNIQQV
ISFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG

Nucleotide


Download         Length: 723 bp        

>NTDB_id=36616 SMUNN2025_RS08745 WP_002263984.1 1812359..1813081(-) (mecA) [Streptococcus mutans NN2025]
ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGCATGGAATT
AAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATT
TCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATC
AATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCTCCGGAGGATTTCTTTAATACCTT
GGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGA
CTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTAATATTCAGCAAGTC
ATAAGTTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGT
TCTGCTTAATCTCGAAGATAAACCTGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAA
CAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGA
TAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-236)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

99.583

100

0.996
  mecA Streptococcus thermophilus LMD-9

57.787

100

0.588
  mecA Streptococcus thermophilus LMG 18311

57.377

100

0.583
  mecA Streptococcus pneumoniae Rx1

48.571

100

0.496
  mecA Streptococcus pneumoniae D39

48.571

100

0.496
  mecA Streptococcus pneumoniae R6

48.571

100

0.496
  mecA Streptococcus pneumoniae TIGR4

48.571

100

0.496

Multiple sequence alignment