Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   SMUNN2025_RS07625 Genome accession   NC_013928
Coordinates   1569104..1570954 (-) Length   616 a.a.
NCBI ID   WP_002263039.1    Uniprot ID   A0AAX1K050
Organism   Streptococcus mutans NN2025     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1564104..1575954
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNN2025_RS07600 (SmuNN2025_1482) - 1564504..1564890 (-) 387 WP_002268943.1 S1 RNA-binding domain-containing protein -
  SMUNN2025_RS07605 (SmuNN2025_1483) - 1564874..1566289 (-) 1416 WP_012997902.1 Cof-type HAD-IIB family hydrolase -
  SMUNN2025_RS07610 (SmuNN2025_1484) - 1566333..1566974 (-) 642 WP_002263036.1 response regulator transcription factor -
  SMUNN2025_RS07615 (SmuNN2025_1485) - 1566967..1567971 (-) 1005 WP_002263037.1 sensor histidine kinase -
  SMUNN2025_RS07620 (SmuNN2025_1486) liaF 1567968..1568663 (-) 696 WP_002263038.1 cell wall-active antibiotics response protein LiaF -
  SMUNN2025_RS07625 (SmuNN2025_1487) pknB 1569104..1570954 (-) 1851 WP_002263039.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SMUNN2025_RS07630 (SmuNN2025_1488) - 1570951..1571694 (-) 744 WP_002263040.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SMUNN2025_RS07635 (SmuNN2025_1489) rsmB 1571733..1573055 (-) 1323 WP_002277406.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  SMUNN2025_RS07640 (SmuNN2025_1490) fmt 1573036..1573971 (-) 936 WP_002266353.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 616 a.a.        Molecular weight: 66913.66 Da        Isoelectric Point: 9.4520

>NTDB_id=36607 SMUNN2025_RS07625 WP_002263039.1 1569104..1570954(-) (pknB) [Streptococcus mutans NN2025]
MIQIGKLFAGRYRILQSIGRGGMADVYLANDLILDNEEVAIKVLRTNYQTDQVAVTRFQREARAMAELNHPNIVAIRDIG
EEDGQQFLAMEYVDGADLKKYIQDHAPLSNAEVIRIMKEVLSAMTLAHQKGIIHRDLKPQNVLLTKDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENKNVP
QALENVVIKATAKRLTDRYHSTQEMLQDLRTSLQPNRSRERKLVFSDASDTKPLPKLEQAAANSLAAQSLKNKTSNQDKV
DHKSKPKTKPQPKPKKKRHFLARFFKIFFILVAIGIAVLTYLVLTKPSTVSVPDVSGDKLSTAKMIIRKSGLKVGDVQKI
EDDNVGAGKVVRTNPSAGSKKREGSSVDIFVASAKGFKMEDYTGQDYKDAIDNLTNNYGVSRDSIVLKEVSSDDYSGGTV
IGQSPKPGKTYHPSSDKKITLKVVKVTMPNLKNSTYEEAVSTLTAMGISSSRIKAYDASDYSSEISSPSSSSLVVGQSPY
YGNTVSLSSNDDIILYVSTSGGSHSGSSSSESSNSEGTTSSEASTDSSSSATTTSH

Nucleotide


Download         Length: 1851 bp        

>NTDB_id=36607 SMUNN2025_RS07625 WP_002263039.1 1569104..1570954(-) (pknB) [Streptococcus mutans NN2025]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATTCTCCAGTCTATCGGACGAGGTGGGATGGCGGATGTTTA
TTTAGCTAATGATTTGATTTTAGATAATGAGGAAGTGGCCATTAAGGTTCTACGTACGAATTATCAGACAGATCAGGTTG
CTGTGACACGTTTTCAGCGGGAAGCACGTGCCATGGCAGAACTTAATCATCCTAATATTGTAGCCATTCGTGACATTGGA
GAAGAAGACGGTCAGCAATTCCTTGCAATGGAATATGTTGATGGCGCCGACTTGAAGAAATACATTCAAGATCACGCTCC
TTTATCAAATGCTGAAGTCATTAGAATCATGAAAGAGGTTCTTTCTGCTATGACTCTTGCCCACCAAAAGGGCATTATTC
ATCGGGATTTAAAACCTCAAAATGTTTTACTGACCAAAGATGGAACGGCTAAAGTAACAGACTTTGGTATTGCTGTGGCT
TTTGCTGAAACGAGTTTGACCCAAACCAATTCAATGCTGGGTTCAGTACATTACTTATCTCCTGAACAGGCGCGTGGTTC
TAAGGCTACTGTTCAAAGTGATATCTATGCAATGGGAATTATGCTTTTTGAAATGCTGACGGGGCATATTCCCTATGATG
GCGATAGTGCTGTTACAATTGCTTTGCAGCATTTTCAAAAGCCTTTACCATCTATTATTGCTGAGAATAAAAATGTCCCT
CAAGCTCTTGAAAATGTTGTTATTAAAGCAACAGCTAAACGATTAACGGACCGCTATCATTCAACGCAGGAGATGTTGCA
GGATTTAAGAACGTCTCTGCAGCCGAATCGCAGCCGTGAAAGAAAGCTTGTTTTCAGTGATGCTTCAGATACCAAACCAC
TACCAAAACTGGAACAGGCAGCAGCAAACTCTTTAGCTGCTCAGTCCTTAAAAAACAAAACTTCCAATCAGGATAAAGTA
GATCATAAATCTAAGCCTAAAACCAAACCACAACCTAAGCCTAAGAAAAAAAGACATTTTTTAGCTCGTTTCTTTAAAAT
CTTCTTTATATTAGTTGCCATTGGTATTGCTGTTTTGACCTACCTGGTTCTGACAAAACCGAGTACTGTTTCAGTTCCTG
ACGTTTCAGGAGATAAATTATCAACGGCCAAGATGATTATTAGAAAATCGGGTCTTAAGGTGGGTGACGTTCAAAAAATT
GAGGATGATAACGTTGGTGCTGGAAAGGTCGTAAGAACTAATCCAAGTGCAGGCAGTAAAAAACGTGAAGGTTCTAGTGT
TGATATTTTTGTAGCTAGTGCTAAGGGATTTAAGATGGAGGACTATACCGGTCAAGATTACAAGGATGCTATTGATAATT
TGACTAATAATTATGGTGTTTCTAGGGACAGTATTGTTCTTAAGGAAGTTTCATCTGATGACTACAGTGGTGGAACTGTT
ATCGGTCAATCACCAAAACCCGGAAAGACCTATCATCCTAGCAGTGATAAAAAAATAACTCTCAAGGTTGTCAAAGTCAC
TATGCCAAATCTTAAAAATTCTACTTATGAAGAGGCTGTCAGTACTTTAACAGCTATGGGGATTTCTTCAAGCCGTATAA
AAGCTTATGATGCCAGCGATTACTCATCAGAAATTTCATCACCATCATCTTCGTCACTCGTTGTCGGTCAAAGTCCTTAT
TATGGTAATACTGTCAGTCTGTCATCTAATGATGATATTATCTTGTATGTTTCAACATCAGGTGGCTCTCATTCTGGTTC
GTCGTCGTCTGAATCTTCGAACAGTGAAGGAACAACATCAAGCGAAGCCTCGACAGACTCTAGTTCAAGTGCGACGACAA
CTTCACATTAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-258)

PASTA domain (PASTA)

(370-432)

PASTA domain (PASTA)

(506-579)

PASTA domain (PASTA)

(438-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

100

100

1
  stkP/pknB Streptococcus salivarius strain HSISS4

62.919

96.753

0.609
  stkP Streptococcus pneumoniae TIGR4

52.381

98.864

0.518
  stkP Streptococcus pneumoniae D39

52.217

98.864

0.516
  stkP Streptococcus pneumoniae R6

52.217

98.864

0.516
  stkP Streptococcus pneumoniae Rx1

52.053

98.864

0.515

Multiple sequence alignment