Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   SMI_RS08220 Genome accession   NC_013853
Coordinates   1671380..1673278 (-) Length   632 a.a.
NCBI ID   WP_000614548.1    Uniprot ID   D3HAG4
Organism   Streptococcus mitis B6     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1666380..1678278
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS08195 (smi_1617) - 1666521..1667486 (+) 966 WP_000226009.1 LacI family DNA-binding transcriptional regulator -
  SMI_RS08200 (smi_1618) - 1667523..1668797 (-) 1275 WP_000704354.1 hydroxymethylglutaryl-CoA reductase, degradative -
  SMI_RS08205 (smi_1619) - 1668797..1669969 (-) 1173 WP_000151949.1 hydroxymethylglutaryl-CoA synthase -
  SMI_RS08210 (smi_1620) - 1670082..1670531 (-) 450 WP_012972578.1 threonine/serine exporter family protein -
  SMI_RS08215 (smi_1621) - 1670533..1671291 (-) 759 WP_000392949.1 threonine/serine exporter family protein -
  SMI_RS08220 (smi_1622) stkP 1671380..1673278 (-) 1899 WP_000614548.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SMI_RS08225 (smi_1623) - 1673275..1674015 (-) 741 WP_000406241.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SMI_RS08230 (smi_1624) rsmB 1674030..1675343 (-) 1314 WP_164925528.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  SMI_RS08235 (smi_1625) fmt 1675336..1676271 (-) 936 WP_000163711.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 632 a.a.        Molecular weight: 69135.59 Da        Isoelectric Point: 9.3770

>NTDB_id=36330 SMI_RS08220 WP_000614548.1 1671380..1673278(-) (stkP) [Streptococcus mitis B6]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIDENPSVP
QALENVVIKATAKKLTDRYKSVAEMYVDLSSSLSYNRRNEPKLVFDDATKADTKTLPKVSQSTLTSIPKVQTQSPKPQTT
KPSQQVSEDNYVTKPVKKRKFRVRYMILLASIVLVAASLIWILSRTPATIAIPDVAGQTVAEAKETLKKANFEIGEEKSE
ASEKVEEGRIIRTDPEAGKTRKEGTKINLVVSSGKQSFQLSNYIGRKSTDVIAELKQKKVPENLIKIEEEESSESEAGTV
LRQSPAAGTTYDLSKASTITLTVAKKVTSVAMPSYTGSSLEFTKNNLVQIVGIKEANIEVVEVSTAPDGTAEGTVVEQSP
KAGEKVDLTKTRVKISIYKPKTPPLTSSSAPSQRGNQGSTTTPSQGNQQGNQRGNAPTTQSSSEGNHENSRD

Nucleotide


Download         Length: 1899 bp        

>NTDB_id=36330 SMI_RS08220 WP_000614548.1 1671380..1673278(-) (stkP) [Streptococcus mitis B6]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTGTGAAACAGATTGGCCGAGGAGGCATGGCAGATGTCTA
TTTGGCCAAGGATTTAATTCTAGACGGAGAAGAAGTGGCAGTGAAGGTCCTGAGGACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATCTAGACCATCCTCATATCGTTCGGATAACAGATATTGGT
GAGGAAGACGGTCAACAGTATCTTGCAATGGAGTATGTTGCTGGACTAGACCTCAAACGTTATATCAAGGAACACTATCC
TCTTTCTAATGAAGAAGCCGTCCGTATCATGGGACAAATCCTCCTAGCCATGCGTTTGGCCCATACCAGAGGAATTGTTC
ACAGGGACTTAAAACCTCAAAATATCCTCTTGACACCGGATGGGACTGCCAAGGTTACAGACTTTGGGATTGCAGTAGCC
TTTGCAGAGACGAGTCTGACTCAGACTAACTCTATGCTGGGCTCAGTTCATTACTTGTCACCTGAGCAGGCGCGTGGTTC
GAAGGCGACTGTACAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGCTGACAGGTCATATTCCTTACGATG
GAGATAGTGCGGTGACCATTGCCCTTCAGCATTTCCAGAAACCACTGCCCTCAGTTATTGATGAAAATCCATCTGTGCCT
CAGGCTTTGGAAAATGTTGTTATCAAGGCAACTGCCAAGAAATTGACAGATCGCTACAAATCAGTAGCTGAAATGTATGT
GGATTTGTCTAGTAGTTTGTCTTATAATCGTCGTAATGAACCAAAGCTGGTCTTTGACGATGCGACTAAGGCGGACACCA
AGACACTACCAAAGGTATCCCAGAGTACCTTGACCTCGATTCCTAAGGTGCAAACACAAAGTCCGAAGCCACAGACTACG
AAGCCGAGTCAGCAGGTTTCAGAAGACAATTACGTAACCAAGCCTGTTAAGAAACGAAAATTTAGAGTTCGTTATATGAT
TTTGTTGGCCAGCATTGTATTGGTGGCAGCTTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCGGAAGCCAAGGAAACGCTCAAGAAAGCCAATTTTGAGATTGGCGAGGAGAAATCAGAG
GCTAGTGAAAAGGTGGAAGAAGGGCGGATTATCCGTACAGATCCTGAAGCTGGAAAGACTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAGCAATCTTTCCAATTGAGCAATTATATCGGCCGTAAATCAACAGATGTTATTGCAG
AACTCAAGCAGAAGAAGGTTCCTGAAAATCTCATCAAGATTGAGGAAGAAGAATCAAGCGAGAGCGAAGCAGGAACCGTT
CTCAGACAGAGTCCAGCTGCTGGAACAACCTATGATTTGAGCAAGGCATCAACGATTACCTTAACCGTTGCTAAGAAAGT
AACCAGCGTTGCCATGCCAAGTTATACAGGATCTAGTCTTGAATTTACTAAAAACAATCTCGTTCAAATTGTCGGTATTA
AAGAAGCCAATATTGAAGTTGTGGAAGTGTCGACAGCTCCTGATGGAACTGCTGAGGGTACAGTCGTTGAACAGAGTCCA
AAAGCGGGTGAAAAGGTTGATTTGACTAAGACGCGTGTCAAGATTTCAATCTACAAACCAAAAACACCGCCGTTAACGTC
ATCATCAGCACCATCCCAACGTGGAAACCAAGGTTCTACTACAACACCAAGTCAGGGGAACCAACAAGGAAATCAACGAG
GGAATGCACCTACTACTCAGTCAAGTAGTGAAGGCAACCACGAAAATTCACGTGATTAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(371-432)

PASTA domain (PASTA)

(510-579)

PASTA domain (PASTA)

(441-505)

Protein kinase domain (Pkinase)

(12-227)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3HAG4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

79.5

94.937

0.755
  stkP Streptococcus pneumoniae D39

79.167

94.937

0.752
  stkP Streptococcus pneumoniae R6

79.167

94.937

0.752
  stkP Streptococcus pneumoniae Rx1

79

94.937

0.75
  stkP/pknB Streptococcus salivarius strain HSISS4

54.53

92.563

0.505
  pknB Streptococcus mutans UA159

55.095

91.614

0.505

Multiple sequence alignment