Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SMI_RS03900 Genome accession   NC_013853
Coordinates   727687..728424 (+) Length   245 a.a.
NCBI ID   WP_000782679.1    Uniprot ID   D3H827
Organism   Streptococcus mitis B6     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 722687..733424
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMI_RS03880 (smi_0768) - 722778..723881 (+) 1104 WP_000225909.1 glycosyltransferase -
  SMI_RS03885 (smi_0769) - 723883..724869 (+) 987 WP_000446968.1 glycosyltransferase family 2 protein -
  SMI_RS03890 (smi_0770) - 724885..726354 (+) 1470 WP_000565077.1 O-antigen polysaccharide polymerase Wzy family protein -
  SMI_RS03895 (smi_0771) - 726347..727381 (+) 1035 WP_000461488.1 hypothetical protein -
  SMI_RS03900 (smi_0772) mecA 727687..728424 (+) 738 WP_000782679.1 adaptor protein MecA Regulator
  SMI_RS03905 (smi_0773) - 728575..729861 (+) 1287 WP_000216350.1 homoserine dehydrogenase -
  SMI_RS03910 (smi_0774) thrB 729863..730732 (+) 870 WP_000692421.1 homoserine kinase -
  SMI_RS03915 (smi_0775) msrB 730946..731884 (+) 939 WP_000818187.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28424.25 Da        Isoelectric Point: 4.0520

>NTDB_id=36310 SMI_RS03900 WP_000782679.1 727687..728424(+) (mecA) [Streptococcus mitis B6]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVSFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LKKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=36310 SMI_RS03900 WP_000782679.1 727687..728424(+) (mecA) [Streptococcus mitis B6]
ATGAAAATGAAACAAATCAGTGATACAACTTTGAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGTTAGAGATGCCTGATAGCT
TTCTAGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTCGATGTCTTTGTAACCAAATCAAAGATT
GATCAAAATCTAGATTTTGAAGACTTATCGGATTTACCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCTTGGAAAAAAGTATCGCAGACAAAACTAAGGATGATATCGAAGCCATTCAATCTCTAGAGCAGGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGCAAGAAAGAGCCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTGTCTTTTGCCAAGACAGTGACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGTCCATATCCAGCTTGGCTGTTGGCTCGTATGCGCGAGT
TTGCGGACGATAGTGATATCAGTCGTTCAGTTTTGCAAGAGTATGGTCAAGTCTTGATGAATCACGATGCAGTGCTTAAT
CTGAAAAAGATTGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D3H827

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

98.367

100

0.984
  mecA Streptococcus pneumoniae D39

98.367

100

0.984
  mecA Streptococcus pneumoniae R6

98.367

100

0.984
  mecA Streptococcus pneumoniae TIGR4

97.959

100

0.98
  mecA Streptococcus mutans UA159

47.755

100

0.478
  mecA Streptococcus thermophilus LMD-9

47.755

100

0.478
  mecA Streptococcus thermophilus LMG 18311

47.347

100

0.473

Multiple sequence alignment