Detailed information NTG0036304

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SMI_RS01900
• Genome accession: NC_013853
• Coordinates: 359732..360469 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219152.1
• Uniprot ID: D3H6Z5
• Organism: Streptococcus mitis B6
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 354732..365469

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMI_RS01870 (smi_0359)	-	356063..356350 (-)	288	WP_000777756.1	hypothetical protein	-
SMI_RS01875 (smi_0360)	-	356360..356770 (-)	411	WP_001278316.1	HIT family protein	-
SMI_RS01880 (smi_0361)	pptA	356838..357569 (+)	732	WP_000889954.1	ABC transporter ATP-binding protein	Regulator
SMI_RS01885 (smi_0362)	pptB	357566..358615 (+)	1050	WP_000653796.1	ABC transporter permease	Regulator
SMI_RS01890 (smi_0363)	-	358677..359006 (-)	330	WP_000132581.1	hypothetical protein	-
SMI_RS01895 (smi_0364)	-	359389..359727 (+)	339	WP_000682130.1	LytTR family DNA-binding domain-containing protein	-
SMI_RS01900 (smi_0365)	comE/blpR	359732..360469 (+)	738	WP_001219152.1	response regulator transcription factor	Regulator
SMI_RS01905 (smi_0366)	-	360483..361832 (+)	1350	WP_001017633.1	sensor histidine kinase	-
SMI_RS01910 (smi_0367)	-	361901..362257 (+)	357	WP_001036313.1	hypothetical protein	-
SMI_RS01915 (smi_0369)	-	362631..363035 (+)	405	WP_000846938.1	hypothetical protein	-
SMI_RS01920 (smi_0370)	-	363119..363502 (+)	384	WP_000877392.1	hypothetical protein	-
SMI_RS01925 (smi_0371)	blpZ	363539..363787 (+)	249	WP_000276503.1	immunity protein BlpZ	-
SMI_RS01930 (smi_0372)	-	363817..364428 (+)	612	WP_001218006.1	CPBP family intramembrane glutamic endopeptidase	-
SMI_RS01935 (smi_0373)	ccrZ	364589..365383 (+)	795	WP_000363007.1	cell cycle regulator CcrZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28839.09 Da
• Isoelectric Point: 6.3934

>NTDB_id=36304 SMI_RS01900 WP_001219152.1 359732..360469(+) (comE/blpR) [Streptococcus mitis B6]
MRIFVLEDDFSQQTRIETTIEKLLKEHQIIPISFEVFGKADQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=36304 SMI_RS01900 WP_001219152.1 359732..360469(+) (comE/blpR) [Streptococcus mitis B6]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCAGATTATTCCTATCTCTTTTGAGGTATTTGGGAAGGCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGAGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAAGGCTTAGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTAATAGTCTTTGTAACAACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCATTGTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAGAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTCTACTAT
CTCGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTTCGTTTGGATA
AGAAAGAAAAACTGCTTTACTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: D3H6Z5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.694	100	0.371