Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   FD735_RS06375 Genome accession   NZ_CP040231
Coordinates   1200081..1200821 (-) Length   246 a.a.
NCBI ID   WP_139659110.1    Uniprot ID   A0A5B7Y8J0
Organism   Streptococcus sp. 1643     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1195081..1205821
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FD735_RS06360 (FD735_06360) msrB 1196576..1197514 (-) 939 WP_139658765.1 peptide-methionine (R)-S-oxide reductase MsrB -
  FD735_RS06365 (FD735_06365) thrB 1197775..1198644 (-) 870 WP_139658766.1 homoserine kinase -
  FD735_RS06370 (FD735_06370) - 1198646..1199932 (-) 1287 WP_139658767.1 homoserine dehydrogenase -
  FD735_RS06375 (FD735_06375) mecA 1200081..1200821 (-) 741 WP_139659110.1 adaptor protein MecA Regulator
  FD735_RS06380 (FD735_06380) - 1200944..1202422 (+) 1479 WP_139658768.1 oligosaccharide flippase family protein -
  FD735_RS06385 (FD735_06385) - 1202468..1204981 (-) 2514 WP_125391221.1 MBL fold metallo-hydrolase -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28583.30 Da        Isoelectric Point: 4.0890

>NTDB_id=362652 FD735_RS06375 WP_139659110.1 1200081..1200821(-) (mecA) [Streptococcus sp. 1643]
MKMKQISDTTLKITMTLDDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDNFLDSGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLADLPDMEELAQMSPDEFLKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQADKETENKKEPYIYYILRFA
SLADLVAFAKTVNYQMETSELYKMNDHYYLTILVDVENHPSPYPAWLLARMREFADDSDISRSVLQEYGHILINHDAVFG
LQKINS

Nucleotide


Download         Length: 741 bp        

>NTDB_id=362652 FD735_RS06375 WP_139659110.1 1200081..1200821(-) (mecA) [Streptococcus sp. 1643]
ATGAAGATGAAACAAATTAGTGATACAACACTGAAAATCACAATGACTTTAGATGATTTGATGGATCGGGGAATGGAGAT
TGCAGACTTTCTCGTTCCTCAGGAAAAAACCGAAGAGTTTTTCTATGCTATTTTAGATGAGTTAGAGATGCCAGACAATT
TCTTGGATAGTGGCATGCTGAGTTTCCGCGTGACGCCAAAACCTGATAAGGTCGACGTCTTTGTGACCAAGTCCAAGATT
GACCAAAATTTGGATTTTGAAGATTTGGCGGATCTACCAGACATGGAAGAATTAGCCCAAATGTCGCCAGATGAATTTCT
CAAAACCTTGGAAAAGAGCATTGCAGATAAGACCAAGGACGATATTGAGGCCATCCAATCTCTAGAGCAGGTCGAAGCAA
AGGAAGAAGAGCAAGAGCAGGCAGACAAGGAGACGGAGAATAAGAAAGAACCTTATATCTACTATATCCTACGCTTTGCA
AGCCTTGCTGACTTAGTTGCTTTTGCAAAGACGGTTAACTACCAGATGGAAACATCTGAACTCTATAAGATGAATGACCA
CTATTATTTGACAATCTTAGTTGATGTGGAGAATCATCCTAGTCCGTATCCAGCCTGGCTCTTGGCTCGTATGCGTGAGT
TTGCAGACGACAGTGATATCAGTCGTTCGGTTTTACAAGAGTATGGTCACATCTTGATCAATCACGACGCTGTGTTCGGT
CTTCAAAAAATTAATTCATAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-238)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5B7Y8J0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

89.388

99.593

0.89
  mecA Streptococcus pneumoniae D39

89.388

99.593

0.89
  mecA Streptococcus pneumoniae R6

89.388

99.593

0.89
  mecA Streptococcus pneumoniae TIGR4

88.98

99.593

0.886
  mecA Streptococcus thermophilus LMD-9

48.594

100

0.492
  mecA Streptococcus thermophilus LMG 18311

48.193

100

0.488
  mecA Streptococcus mutans UA159

48.571

99.593

0.484

Multiple sequence alignment