Detailed information NTG0362640

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: FD735_RS03835
• Genome accession: NZ_CP040231
• Coordinates: 702283..704514 (+)
• Length: 743 a.a.
• NCBI ID: WP_139658523.1
• Uniprot ID: A0A5B7Y5H2
• Organism: Streptococcus sp. 1643
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 697283..709514

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FD735_RS03800 (FD735_03800)	-	697789..698394 (+)	606	WP_042902395.1	GrpB family protein	-
FD735_RS03805 (FD735_03805)	-	698391..698606 (+)	216	WP_001232084.1	YozE family protein	-
FD735_RS03810 (FD735_03810)	-	698687..699673 (+)	987	WP_139658518.1	PhoH family protein	-
FD735_RS03815 (FD735_03815)	ald	699724..700836 (-)	1113	WP_139658520.1	alanine dehydrogenase	-
FD735_RS03825 (FD735_03825)	-	701013..701582 (+)	570	WP_139658521.1	GNAT family N-acetyltransferase	-
FD735_RS03830 (FD735_03830)	comEA/celA/cilE	701649..702299 (+)	651	WP_139658522.1	helix-hairpin-helix domain-containing protein	Machinery gene
FD735_RS03835 (FD735_03835)	comEC/celB	702283..704514 (+)	2232	WP_139658523.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
FD735_RS09910	-	704664..704878 (+)	215	Protein_691	hypothetical protein	-
FD735_RS03840 (FD735_03840)	-	704911..705504 (+)	594	WP_139658524.1	ATP-binding cassette domain-containing protein	-
FD735_RS03845 (FD735_03845)	-	705501..706685 (+)	1185	WP_139658525.1	hypothetical protein	-
FD735_RS03850 (FD735_03850)	infC	706991..707521 (+)	531	WP_000848184.1	translation initiation factor IF-3	-
FD735_RS03855 (FD735_03855)	rpmI	707554..707754 (+)	201	WP_001125942.1	50S ribosomal protein L35	-
FD735_RS03860 (FD735_03860)	rplT	707806..708165 (+)	360	WP_000124830.1	50S ribosomal protein L20	-

Sequence

Protein

• Length: 743 a.a.
• Molecular weight: 84542.70 Da
• Isoelectric Point: 8.7152

>NTDB_id=362640 FD735_RS03835 WP_139658523.1 702283..704514(+) (comEC/celB) [Streptococcus sp. 1643]
MSQWIKNFPIPLIYLSFLLLWLYYAIFGASYLALLGFVFLLVCLFFQFPWKSAGKVLAICGVFGFWFLFQTWQQSQASQN
LVDSVERVRILPDTIKVNGDSLSFRGKAEAHTFQVYYKLQSEEEKELFQTLTDLHEIELEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLTIKSIQSMKQVSSWDIRENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDAFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGIKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGDGIKVVARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDVVFLPLLSI
LFILSFIYPVTQFNFVFEWLENIIRLVSQLASRPLVFGQPNAWLLILLLVLLALVYDMRKNIKRLAGFSLFIVGLFFLTK
HPLENEITLLDVGQGESIFLRDMAGKTILIDVGGKAESDKKIQAWQEKATTSNAQRTLIPYLKSRGVDKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSRGSLTQKEFVAELEASQNKVRSVTAGENFPIFGSYLEVLSPRQIGDEDRDGSLVLYGKL
LDKHFLFTGNLKEKDLLKQYPDLEVDVLKAGQHGAKTSSNPTFLEKLKPEITLISVGKNNRAKLPHQETLTRLEIIKSKI
YRTDQQGAIRFTGWNSWQIESVR

Nucleotide

• Length: 2232 bp

>NTDB_id=362640 FD735_RS03835 WP_139658523.1 702283..704514(+) (comEC/celB) [Streptococcus sp. 1643]
ATGTCACAGTGGATTAAGAATTTCCCTATCCCCCTAATCTATCTGAGTTTTCTATTGCTCTGGCTTTACTACGCCATTTT
TGGAGCGTCCTATCTCGCACTGCTAGGTTTTGTTTTTTTGCTCGTCTGTCTCTTTTTCCAATTTCCTTGGAAATCGGCTG
GAAAAGTTCTAGCGATTTGTGGAGTTTTTGGATTTTGGTTTCTGTTTCAAACTTGGCAACAAAGTCAAGCTAGTCAAAAC
CTAGTGGATTCTGTTGAAAGGGTACGGATTTTGCCTGACACTATTAAGGTCAATGGAGATAGTCTATCCTTTCGGGGCAA
GGCTGAGGCTCACACCTTCCAAGTTTACTATAAACTCCAGTCCGAGGAAGAGAAAGAGCTCTTTCAGACCTTAACAGACC
TTCATGAGATTGAACTAGAAGGAAAACTTTCGGAACCCGAAGGGCAGAGGAATTTTGGTGGCTTTAACTACCAAGCCTAT
CTGAAGACTCAAGGAATTTACCAAACTTTGACTATCAAGAGTATCCAGTCAATGAAACAGGTTAGCAGTTGGGATATAAG
AGAAAATCTGTCTAGTTTACGTCGAAAGGCTGTAGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAACTACATGA
CAGGTCTTCTTTTAGGACATTTGGACACGGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTTGGAATTATCCATCTA
TTTGCCTTGTCAGGTATGCAAGTGGGCTTCTTTATGGATGCCTTTAAGAAACTCCTCTTGCGATTGGGCTTGACCCAAGA
GAAGTTGAAGTGGCTAACTTATCCCTTTTCTCTTATCTATGCAGGTCTGACAGGATTTTCAGCTTCAGTCATTCGCAGTC
TCTTGCAAAAGTTACTGGCCCAACATGGTATTAAGGGTTTGGATAATTTTGCCTTGACGGTCCTTGTCCTTTTTATCATT
ATGCCAAACTTTTTCCTAACTGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCTTGACCATGACTAGCAAAGAAGG
CGATGGGATCAAGGTAGTTGCCAGAGAAAGTTTGGTCATTTCTTTGGGAATATTGCCCATTCTATCCTTCTATTTTGCAG
AATTTCAGCCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTGTTTGATGTGGTTTTCTTGCCGCTTTTGTCCATC
TTATTCATTCTGTCTTTTATTTACCCAGTCACTCAGTTTAACTTTGTCTTTGAGTGGTTGGAGAACATCATTCGCTTGGT
ATCGCAGCTGGCAAGCAGGCCTCTGGTCTTTGGTCAACCCAACGCATGGCTGTTGATTCTACTGTTAGTTTTATTAGCCT
TGGTCTATGACATGAGGAAAAACATCAAAAGACTAGCAGGATTCAGTCTCTTTATTGTGGGGCTCTTTTTCCTGACCAAA
CACCCACTGGAAAATGAAATCACCTTGCTGGATGTAGGGCAAGGTGAAAGCATTTTTCTACGTGATATGGCTGGTAAAAC
CATTCTCATAGATGTGGGAGGTAAAGCAGAATCTGACAAGAAAATCCAAGCTTGGCAGGAAAAGGCGACGACCAGCAATG
CCCAGCGTACCTTGATTCCCTATCTTAAAAGTCGAGGAGTAGATAAGATTGACCAGCTAATTTTGACCAATACAGACAAG
GAACATGTTGGTGATTTGCTGGAGGTGACCAAGGCTTTCCATGTTGGGGAGATTTTAGTATCAAGAGGAAGTCTGACACA
GAAGGAATTTGTAGCGGAACTAGAAGCAAGTCAAAACAAGGTACGTAGTGTGACAGCTGGGGAGAATTTCCCGATTTTTG
GCAGTTACTTAGAAGTCCTATCTCCAAGGCAGATTGGAGATGAGGATCGTGATGGTTCTCTGGTTCTTTATGGAAAACTT
TTGGATAAGCACTTTCTCTTCACAGGAAATTTGAAAGAGAAGGATCTTCTAAAGCAATACCCTGACTTAGAGGTGGATGT
CCTGAAAGCAGGCCAACATGGTGCTAAAACATCATCAAATCCAACTTTCCTAGAAAAACTCAAACCAGAAATTACTCTTA
TTTCAGTTGGAAAGAACAATCGTGCGAAACTCCCCCATCAGGAAACCTTGACACGACTAGAAATCATCAAGAGTAAGATT
TACCGAACTGACCAGCAAGGGGCTATCCGCTTTACAGGGTGGAATAGTTGGCAGATTGAAAGTGTTCGTTAG

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-637)

• Domain of unknown function (DUF4131) (DUF4131) (31-176)

3D structure

• AlphaFold DB: A0A5B7Y5H2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	87.534	100	0.879
comEC/celB	Streptococcus mitis NCTC 12261	86.577	100	0.868
comEC/celB	Streptococcus pneumoniae TIGR4	85.791	100	0.861
comEC/celB	Streptococcus pneumoniae Rx1	85.255	100	0.856
comEC/celB	Streptococcus pneumoniae D39	85.255	100	0.856
comEC/celB	Streptococcus pneumoniae R6	85.255	100	0.856
comEC	Lactococcus lactis subsp. cremoris KW2	44.818	100	0.448