Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   E8M06_RS09215 Genome accession   NZ_CP039462
Coordinates   1870350..1871072 (-) Length   240 a.a.
NCBI ID   WP_002938171.1    Uniprot ID   A0A116M1G6
Organism   Streptococcus suis strain WUSS351     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IScluster/Tn 1871149..1878582 1870350..1871072 flank 77


Gene organization within MGE regions


Location: 1870350..1878582
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E8M06_RS09215 (E8M06_09225) mecA 1870350..1871072 (-) 723 WP_002938171.1 adaptor protein MecA Regulator
  E8M06_RS09220 (E8M06_09230) - 1871123..1872642 (-) 1520 Protein_1741 IS1182 family transposase -
  E8M06_RS09225 (E8M06_09235) - 1872768..1873604 (-) 837 WP_015647359.1 undecaprenyl-diphosphate phosphatase -
  E8M06_RS09230 (E8M06_09240) - 1873731..1875296 (+) 1566 WP_024412905.1 ABC transporter substrate-binding protein/permease -
  E8M06_RS09235 (E8M06_09245) - 1875289..1876032 (+) 744 WP_012775335.1 amino acid ABC transporter ATP-binding protein -
  E8M06_RS09240 (E8M06_09250) - 1876861..1878582 (-) 1722 WP_136581089.1 IS1634 family transposase -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 27973.51 Da        Isoelectric Point: 4.0497

>NTDB_id=358865 E8M06_RS09215 WP_002938171.1 1870350..1871072(-) (mecA) [Streptococcus suis strain WUSS351]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQSLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFT
FVGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDTKLTRPALQEHGTLMLPLAAIEELRKVPTV

Nucleotide


Download         Length: 723 bp        

>NTDB_id=358865 E8M06_RS09215 WP_002938171.1 1870350..1871072(-) (mecA) [Streptococcus suis strain WUSS351]
ATGAAAGTAAAGCAAATTAGTGATTCAACCTTGAAAATCACTATAAAATTAGATGATTTGGAAGAGAGAGGAATGGAACT
TTCGGACTTTCTCATTCCGCAAGAAAAGACAGAGGAGTTCTTCTATACTGTTTTGGATGAATTGGATTTACCAATGACTT
TCCGAGAAAGCGGTATGCTGAGTTTTCGTGTGACTCCGAAGCCAGATCGGGTGGACATATTTGTTACCAAATCTGATTTG
GATCAGAGCTTGAATTTCGATGAATTTACAGATTTGTCAGAACTTGGTGATGTCGCAAGTATGACTCCAGATGAGTTTTT
CAAGAGTTTGGAGCAAACCGTTCGTGAGAAAAGCGCACCGGATGCAACAGCCGTTCGTCATTTGGAAGAGGTAGAGCAAG
AGGAAGAAGCAGATGAAGAGGAGCAGGAGCGCTATATTTACTATATTTTGGAATTTCCAACGATAGAGGATCTGTTTACT
TTTGTTGGTACGGTTGATTATCCAGTAGAAGAATCGGAATTATATAAAATGGATGGTCACTACTACTTGACCGTTCTTAT
CAATGTAGAAAATCGTTCCAAGCAGTATCCAGGCTACATTCTCTCAAGAATGTTGGAATTTACCAATGATACTAAGTTGA
CCAGACCTGCTTTACAAGAACACGGAACTTTGATGCTTCCGCTTGCGGCAATCGAGGAGCTTAGGAAGGTTCCGACAGTA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A116M1G6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

51.639

100

0.525
  mecA Streptococcus pneumoniae D39

51.639

100

0.525
  mecA Streptococcus pneumoniae R6

51.639

100

0.525
  mecA Streptococcus pneumoniae TIGR4

51.639

100

0.525
  mecA Streptococcus mutans UA159

50

100

0.508
  mecA Streptococcus thermophilus LMD-9

47.5

100

0.475
  mecA Streptococcus thermophilus LMG 18311

47.083

100

0.471

Multiple sequence alignment