Detailed information NTG0358843

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: E8M06_RS04505
• Genome accession: NZ_CP039462
• Coordinates: 903159..903830 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain WUSS351
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 898159..908830

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E8M06_RS04475 (E8M06_04480)	pstC	898249..899166 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
E8M06_RS04480 (E8M06_04485)	pstA	899156..900043 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
E8M06_RS04485 (E8M06_04490)	pstB	900068..900871 (+)	804	WP_024413123.1	phosphate ABC transporter ATP-binding protein PstB	-
E8M06_RS04490 (E8M06_04495)	pstB	900883..901641 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
E8M06_RS04495 (E8M06_04500)	phoU	901670..902326 (+)	657	WP_136581248.1	phosphate signaling complex protein PhoU	-
E8M06_RS04500 (E8M06_04505)	-	902492..902965 (+)	474	WP_136581249.1	hypothetical protein	-
E8M06_RS04505 (E8M06_04510)	ciaR	903159..903830 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
E8M06_RS04510 (E8M06_04515)	ciaH	903823..905202 (+)	1380	WP_136581250.1	HAMP domain-containing sensor histidine kinase	Regulator
E8M06_RS04515 (E8M06_04520)	-	905303..906532 (+)	1230	WP_044679497.1	transglutaminase domain-containing protein	-
E8M06_RS04520 (E8M06_04525)	rpsT	906795..907043 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
E8M06_RS04525 (E8M06_04530)	coaA	907102..908022 (-)	921	WP_002935283.1	type I pantothenate kinase	-
E8M06_RS04530 (E8M06_04535)	-	908131..908721 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=358843 E8M06_RS04505 WP_014637852.1 903159..903830(+) (ciaR) [Streptococcus suis strain WUSS351]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=358843 E8M06_RS04505 WP_014637852.1 903159..903830(+) (ciaR) [Streptococcus suis strain WUSS351]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCATTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAATACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368