NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	GO602_RS13900	Genome accession	NZ_CP046602
Coordinates	3051534..3052205 (-)	Length	223 a.a.
NCBI ID	WP_003090494.1	Uniprot ID	A0A0H2ZC88
Organism	Pseudomonas aeruginosa strain CMC-115
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 3046534..3057205

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GO602_RS29985	-	3047871..3048890 (+)	1020	Protein_2756	chemotaxis protein	-
GO602_RS29990	-	3049290..3049796 (+)	507	Protein_2757	methyl-accepting chemotaxis protein	-
GO602_RS13890 (GO602_13880)	-	3049801..3050109 (-)	309	WP_024915899.1	hypothetical protein	-
GO602_RS13895 (GO602_13885)	carS	3050200..3051537 (-)	1338	WP_168334399.1	two-component system sensor histidine kinase CarS	-
GO602_RS13900 (GO602_13890)	ciaR	3051534..3052205 (-)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
GO602_RS13905 (GO602_13895)	-	3052205..3052519 (-)	315	WP_003097704.1	PepSY domain-containing protein	-
GO602_RS13910 (GO602_13900)	-	3052519..3052827 (-)	309	WP_003090497.1	PepSY domain-containing protein	-
GO602_RS13915 (GO602_13905)	-	3053037..3054119 (+)	1083	WP_024915897.1	hypothetical protein	-
GO602_RS13920 (GO602_13910)	-	3054146..3055039 (+)	894	WP_024915896.1	hypothetical protein	-
GO602_RS13925 (GO602_13915)	-	3055023..3055289 (+)	267	WP_024915895.1	DUF5329 domain-containing protein	-
GO602_RS13930 (GO602_13920)	-	3055290..3056489 (-)	1200	WP_121366914.1	NnrS family protein	-
GO602_RS13935 (GO602_13925)	ppyR	3056476..3056733 (-)	258	WP_024915893.1	psl/pyoverdine operon transcriptional regulator PpyR	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 24729.20 Da Isoelectric Point: 5.8445

                                >NTDB_id=353860 GO602_RS13900 WP_003090494.1 3051534..3052205(-) (ciaR) [Pseudomonas aeruginosa strain CMC-115]

MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA

RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR

YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

Download Length: 672 bp

                                >NTDB_id=353860 GO602_RS13900 WP_003090494.1 3051534..3052205(-) (ciaR) [Pseudomonas aeruginosa strain CMC-115]

ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCGCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT

GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGTGCCAGCGAACCCTACGACCTGATCATCCTCGATCTCGGCC

TGCCCGGGCGTCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGCCTGGGCCTTGCGACTCCGGTGCTGATCCTCACCGCG

CGCGGTTCCTGGGCCGAACGCATCGATGGGCTCAAGGCCGGCGCCGACGACTACCTGACCAAGCCGTTCCATCCTGAAGA

GCTGGCCCTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCCGGGCTGC

GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC

TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA

TTCCAATGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG

GCTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-216)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0H2ZC88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363

Detailed information NTG0353860