Detailed information NTG0352628

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ES276_RS04570
• Genome accession: NZ_CP038252
• Coordinates: 881695..882432 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 876695..887432

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS04540 (ES276_04875)	-	878027..878314 (-)	288	WP_000777760.1	hypothetical protein	-
ES276_RS04545 (ES276_04880)	-	878324..878734 (-)	411	WP_001278301.1	HIT family protein	-
ES276_RS04550 (ES276_04885)	pptA	878802..879533 (+)	732	WP_000889924.1	ABC transporter ATP-binding protein	Regulator
ES276_RS04555 (ES276_04890)	-	879530..880579 (+)	1050	WP_000653779.1	ABC transporter permease	-
ES276_RS04560 (ES276_04900)	-	880747..881076 (-)	330	WP_000132572.1	hypothetical protein	-
ES276_RS04565 (ES276_04905)	-	881352..881690 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
ES276_RS04570 (ES276_04910)	comE/blpR	881695..882432 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
ES276_RS04575 (ES276_04915)	-	882446..883786 (+)	1341	WP_001017646.1	sensor histidine kinase	-
ES276_RS04580 (ES276_04920)	blpC	883857..883985 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
ES276_RS04585 (ES276_04925)	-	884042..885412 (-)	1371	WP_001069077.1	bacteriocin secretion accessory protein	-
ES276_RS10920 (ES276_04930)	comA/nlmT	885423..886070 (-)	648	WP_322349254.1	ATP-binding cassette domain-containing protein	Regulator
ES276_RS10925 (ES276_04935)	comA/nlmT	886086..887099 (-)	1014	WP_307772067.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=352628 ES276_RS04570 WP_001219120.1 881695..882432(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901936]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=352628 ES276_RS04570 WP_001219120.1 881695..882432(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901936]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363