Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   E3O58_RS06730 Genome accession   NZ_CP038177
Coordinates   1300019..1301305 (+) Length   428 a.a.
NCBI ID   WP_002325236.1    Uniprot ID   A0A366TVN3
Organism   Enterococcus faecium strain HN11     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1295019..1306305
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3O58_RS06705 (E3O58_07030) - 1295314..1296366 (-) 1053 WP_002291912.1 PTS sugar transporter subunit IIC -
  E3O58_RS06710 (E3O58_07035) - 1296379..1297317 (-) 939 WP_002291914.1 2-dehydropantoate 2-reductase -
  E3O58_RS06715 (E3O58_07040) - 1297768..1298418 (-) 651 WP_002334439.1 hypothetical protein -
  E3O58_RS06720 (E3O58_07045) - 1298518..1299027 (-) 510 WP_142431455.1 DUF1456 family protein -
  E3O58_RS06725 (E3O58_07050) rlmH 1299112..1299591 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E3O58_RS06730 (E3O58_07055) htrA 1300019..1301305 (+) 1287 WP_002325236.1 S1C family serine protease Regulator
  E3O58_RS06735 (E3O58_07060) ytpR 1301344..1301949 (-) 606 WP_010717984.1 YtpR family tRNA-binding protein -
  E3O58_RS06740 (E3O58_07065) - 1302154..1302618 (-) 465 WP_002287838.1 universal stress protein -
  E3O58_RS06745 (E3O58_07070) - 1302640..1302960 (-) 321 WP_002287837.1 thioredoxin family protein -
  E3O58_RS06750 (E3O58_07075) pepA 1303103..1304182 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  E3O58_RS06755 (E3O58_07080) - 1304382..1304732 (+) 351 WP_265460814.1 PepSY domain-containing protein -
  E3O58_RS06760 (E3O58_07085) - 1304955..1305902 (+) 948 WP_002289860.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.81 Da        Isoelectric Point: 4.5419

>NTDB_id=352106 E3O58_RS06730 WP_002325236.1 1300019..1301305(+) (htrA) [Enterococcus faecium strain HN11]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=352106 E3O58_RS06730 WP_002325236.1 1300019..1301305(+) (htrA) [Enterococcus faecium strain HN11]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGCCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGTGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A366TVN3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465

Multiple sequence alignment