Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   E3T36_RS12275 Genome accession   NZ_CP038168
Coordinates   2531239..2532525 (+) Length   428 a.a.
NCBI ID   WP_002325236.1    Uniprot ID   A0A366TVN3
Organism   Enterococcus faecium strain SCBC1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2526239..2537525
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3T36_RS12245 (E3T36_12850) - 2527137..2527484 (+) 348 WP_160232001.1 thioredoxin family protein -
  E3T36_RS12250 (E3T36_12855) - 2527777..2528037 (-) 261 WP_002328071.1 hypothetical protein -
  E3T36_RS12255 (E3T36_12860) - 2528192..2529338 (+) 1147 Protein_2357 IS3 family transposase -
  E3T36_RS12260 - 2529532..2529810 (-) 279 WP_346802664.1 hypothetical protein -
  E3T36_RS12265 - 2529924..2530295 (-) 372 WP_346802665.1 hypothetical protein -
  E3T36_RS12270 (E3T36_12870) rlmH 2530332..2530811 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E3T36_RS12275 (E3T36_12875) htrA 2531239..2532525 (+) 1287 WP_002325236.1 S1C family serine protease Regulator
  E3T36_RS12280 (E3T36_12880) ytpR 2532564..2533169 (-) 606 WP_010717984.1 YtpR family tRNA-binding protein -
  E3T36_RS12285 (E3T36_12885) - 2533374..2533838 (-) 465 WP_002287838.1 universal stress protein -
  E3T36_RS12290 (E3T36_12890) - 2533860..2534180 (-) 321 WP_002287837.1 thioredoxin family protein -
  E3T36_RS12295 (E3T36_12895) pepA 2534323..2535402 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  E3T36_RS12300 (E3T36_12900) - 2535602..2535952 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  E3T36_RS12305 (E3T36_12905) - 2536175..2537122 (+) 948 WP_002289860.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.81 Da        Isoelectric Point: 4.5419

>NTDB_id=351982 E3T36_RS12275 WP_002325236.1 2531239..2532525(+) (htrA) [Enterococcus faecium strain SCBC1]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=351982 E3T36_RS12275 WP_002325236.1 2531239..2532525(+) (htrA) [Enterococcus faecium strain SCBC1]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGCCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGTGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A366TVN3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465

Multiple sequence alignment