Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   E3O52_RS06575 Genome accession   NZ_CP038164
Coordinates   1390454..1391740 (+) Length   428 a.a.
NCBI ID   WP_002328067.1    Uniprot ID   -
Organism   Enterococcus faecium strain HB2-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1385454..1396740
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3O52_RS06550 (E3O52_06890) - 1385908..1386591 (-) 684 WP_002335147.1 PHP domain-containing protein -
  E3O52_RS06555 (E3O52_06900) - 1387521..1387994 (-) 474 WP_272024894.1 hypothetical protein -
  E3O52_RS06560 (E3O52_06905) - 1388123..1388998 (-) 876 WP_272024895.1 PD-(D/E)XK nuclease family protein -
  E3O52_RS06565 - 1389202..1389345 (-) 144 WP_272024897.1 hypothetical protein -
  E3O52_RS06570 (E3O52_06910) rlmH 1389547..1390026 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  E3O52_RS06575 (E3O52_06915) htrA 1390454..1391740 (+) 1287 WP_002328067.1 S1C family serine protease Regulator
  E3O52_RS06580 (E3O52_06920) ytpR 1391779..1392384 (-) 606 WP_002328066.1 YtpR family tRNA-binding protein -
  E3O52_RS06585 (E3O52_06925) - 1392589..1393053 (-) 465 WP_002287838.1 universal stress protein -
  E3O52_RS06590 (E3O52_06930) - 1393075..1393395 (-) 321 WP_002287837.1 thioredoxin family protein -
  E3O52_RS06595 (E3O52_06935) pepA 1393538..1394617 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  E3O52_RS06600 (E3O52_06940) - 1394817..1395167 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  E3O52_RS06605 (E3O52_06945) - 1395390..1396337 (+) 948 WP_002289860.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44854.84 Da        Isoelectric Point: 4.5419

>NTDB_id=351883 E3O52_RS06575 WP_002328067.1 1390454..1391740(+) (htrA) [Enterococcus faecium strain HB2-2]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQNQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=351883 E3O52_RS06575 WP_002328067.1 1390454..1391740(+) (htrA) [Enterococcus faecium strain HB2-2]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCGGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAACCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ATGGAAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGACAGCAAGGTCTAGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGATAAAGTCGA
AACGGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATTGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAACGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465

Multiple sequence alignment