Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGD   Type   Machinery gene
Locus tag   MGAS15252_RS00595 Genome accession   NC_017040
Coordinates   98085..98513 (+) Length   142 a.a.
NCBI ID   WP_002986548.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 93085..103513
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS00575 (MGAS15252_0119) - 95430..95795 (+) 366 WP_002986560.1 DUF1033 family protein -
  MGAS15252_RS00580 (MGAS15252_0120) comGA 95888..96812 (+) 925 Protein_81 competence type IV pilus ATPase ComGA -
  MGAS15252_RS00585 (MGAS15252_0121) comGB 96748..97782 (+) 1035 WP_227868709.1 competence type IV pilus assembly protein ComGB Machinery gene
  MGAS15252_RS00590 (MGAS15252_0122) comGC 97784..98110 (+) 327 WP_014407214.1 competence type IV pilus major pilin ComGC Machinery gene
  MGAS15252_RS00595 (MGAS15252_0123) comGD 98085..98513 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD Machinery gene
  MGAS15252_RS00600 (MGAS15252_0124) comGE 98470..98754 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE Machinery gene
  MGAS15252_RS00605 (MGAS15252_0125) comGF 98747..99181 (+) 435 WP_014407215.1 competence type IV pilus minor pilin ComGF Machinery gene
  MGAS15252_RS00610 (MGAS15252_0126) comGG 99165..99491 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  MGAS15252_RS00615 (MGAS15252_0127) comGH 99589..100542 (+) 954 WP_014407216.1 class I SAM-dependent methyltransferase Machinery gene
  MGAS15252_RS00620 (MGAS15252_0128) - 100601..101797 (+) 1197 WP_014407217.1 acetate kinase -
  MGAS15252_RS00625 (MGAS15252_0129) - 101984..102292 (+) 309 WP_041174321.1 hypothetical protein -
  MGAS15252_RS00630 (MGAS15252_0130) proC 102375..103145 (-) 771 WP_014407219.1 pyrroline-5-carboxylate reductase -

Sequence

Protein


Download         Length: 142 a.a.        Molecular weight: 16310.04 Da        Isoelectric Point: 10.3481

>NTDB_id=35016 MGAS15252_RS00595 WP_002986548.1 98085..98513(+) (comGD) [Streptococcus pyogenes MGAS15252]
MKKPVLAIKAFTLLETLLSLSVMSFIILGLSVPVTKSYQKVEEHLFFSHFEHLYRHQQKLAILQQKQRVLDISSTKIVTE
GNSLTVPKSITVNHPYRLVIDQMGGNHSLAKIIFDMTDRRFKYQFYLGSGNYQKTSQSLHSP

Nucleotide


Download         Length: 429 bp        

>NTDB_id=35016 MGAS15252_RS00595 WP_002986548.1 98085..98513(+) (comGD) [Streptococcus pyogenes MGAS15252]
ATGAAAAAGCCCGTCTTAGCAATTAAAGCTTTTACTTTGCTTGAAACTTTACTAAGTTTGTCAGTGATGAGTTTCATTAT
ATTGGGATTGTCTGTACCAGTGACAAAAAGCTATCAAAAAGTAGAAGAGCATCTGTTTTTTAGCCATTTTGAACATTTGT
ATCGACATCAGCAAAAGTTAGCCATATTACAGCAAAAACAGCGCGTCTTGGATATTTCTTCAACAAAAATTGTTACAGAA
GGTAATAGCCTAACAGTTCCTAAATCAATAACAGTGAATCATCCTTATCGGTTAGTTATTGATCAGATGGGAGGCAACCA
TTCCTTAGCTAAAATTATTTTTGACATGACTGATCGACGCTTTAAATACCAATTTTATCTAGGGAGTGGGAATTATCAAA
AAACAAGTCAAAGCTTACATAGCCCTTGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGD Streptococcus mutans UA159

45.736

90.845

0.415
  comGD Streptococcus mutans UA140

45.736

90.845

0.415
  comGD/cglD Streptococcus mitis NCTC 12261

40.441

95.775

0.387
  comGD Streptococcus gordonii str. Challis substr. CH1

40.458

92.254

0.373
  comGD/cglD Streptococcus mitis SK321

39.695

92.254

0.366
  comGD/cglD Streptococcus pneumoniae Rx1

39.695

92.254

0.366
  comGD/cglD Streptococcus pneumoniae D39

39.695

92.254

0.366
  comGD/cglD Streptococcus pneumoniae R6

39.695

92.254

0.366

Multiple sequence alignment