Detailed information NTG0349437

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EZ612_RS00265
• Genome accession: NZ_CP036531
• Coordinates: 47112..48023 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain STAB10048
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42112..53023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EZ612_RS00245 (EZ612_00245)	purE	42699..43190 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EZ612_RS00250 (EZ612_00250)	purK	43177..44250 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EZ612_RS00255 (EZ612_00255)	-	44252..45670 (+)	1419	WP_023612101.1	hypothetical protein	-
EZ612_RS00260 (EZ612_00260)	purB	45690..46982 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
EZ612_RS00265 (EZ612_00265)	comR	47112..48023 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
EZ612_RS08870	comS	48107..48202 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
EZ612_RS00270 (EZ612_00270)	ruvB	48249..49247 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
EZ612_RS00275 (EZ612_00275)	-	49385..49822 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
EZ612_RS00280 (EZ612_00280)	-	49846..50247 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
EZ612_RS00285 (EZ612_00285)	-	50244..52019 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=349437 EZ612_RS00265 WP_002986681.1 47112..48023(+) (comR) [Streptococcus pyogenes strain STAB10048]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=349437 EZ612_RS00265 WP_002986681.1 47112..48023(+) (comR) [Streptococcus pyogenes strain STAB10048]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462