Detailed information NTG0034358

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: SDEG_RS00290
• Genome accession: NC_012891
• Coordinates: 49951..50862 (+)
• Length: 303 a.a.
• NCBI ID: WP_012766420.1
• Uniprot ID: -
• Organism: Streptococcus dysgalactiae subsp. equisimilis GGS_124
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 44951..55862

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SDEG_RS00265 (SDEG_0052)	purE	45452..45940 (+)	489	WP_012766417.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SDEG_RS00270 (SDEG_0053)	purK	45927..47000 (+)	1074	WP_012766418.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SDEG_RS00275 (SDEG_0054)	-	47010..48266 (+)	1257	WP_012766419.1	DUF4041 domain-containing protein	-
SDEG_RS00280	-	48259..48468 (+)	210	WP_014611912.1	hypothetical protein	-
SDEG_RS00285 (SDEG_0055)	purB	48517..49809 (+)	1293	WP_003056595.1	adenylosuccinate lyase	-
SDEG_RS00290 (SDEG_0056)	comR	49951..50862 (+)	912	WP_012766420.1	helix-turn-helix domain-containing protein	Regulator
SDEG_RS11265	comS	50949..51044 (+)	96	WP_198455558.1	quorum-sensing system DWW-type pheromone	Regulator
SDEG_RS00295 (SDEG_0057)	ruvB	51097..52095 (+)	999	WP_003061489.1	Holliday junction branch migration DNA helicase RuvB	-
SDEG_RS00300 (SDEG_0058)	-	52230..52661 (+)	432	WP_012766422.1	low molecular weight protein-tyrosine-phosphatase	-
SDEG_RS00305 (SDEG_0059)	-	52690..53091 (+)	402	WP_003049089.1	MORN repeat-containing protein	-
SDEG_RS00310 (SDEG_0060)	-	53088..54863 (+)	1776	WP_003059359.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35726.31 Da
• Isoelectric Point: 4.5798

>NTDB_id=34358 SDEG_RS00290 WP_012766420.1 49951..50862(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEQLIIECLQATLDTLLSENINFGVELLQEYFKQTKVKLRFKQND
LILIELYLAYLDIEGMYGEYSDKVFYDSLLDNLLKQFDDFELDELFIVNKIIIDISSLSIKTNKLDNLEKTIAISQKIMA
KIQDWNRMPILKLIEWKYFLIKQKNRKQAEESYTKACLFAQITGDKYLEEQLIKEWEKDICAY

Nucleotide

• Length: 912 bp

>NTDB_id=34358 SDEG_RS00290 WP_012766420.1 49951..50862(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis GGS_124]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAACAATTGATTATAGAATGTTTACAGGCTACGCTAGACACTTTATTAAGTG
AAAACATCAATTTTGGTGTCGAATTATTGCAGGAATATTTTAAACAAACCAAAGTTAAACTACGTTTTAAACAAAACGAC
TTGATACTTATTGAACTCTATCTGGCTTATCTCGATATTGAAGGGATGTATGGAGAATATTCTGATAAGGTTTTTTATGA
TTCTTTGTTAGATAACCTGTTAAAACAATTCGATGACTTTGAATTAGACGAACTGTTCATAGTTAATAAAATTATTATTG
ATATTTCTTCTTTAAGTATTAAAACTAATAAACTAGATAATCTAGAAAAGACGATTGCTATAAGTCAAAAAATCATGGCA
AAAATCCAGGATTGGAATAGAATGCCTATACTAAAATTAATAGAATGGAAGTACTTTTTAATAAAACAAAAGAACAGAAA
ACAAGCAGAGGAATCATATACAAAGGCGTGTCTGTTTGCGCAAATAACAGGAGACAAGTATTTGGAAGAGCAATTAATCA
AAGAATGGGAGAAAGATATTTGTGCTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	82.178	100	0.822
comR	Streptococcus pyogenes MGAS315	54.667	99.01	0.541
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	50.847	97.36	0.495
comR	Streptococcus mutans UA159	49.498	98.68	0.488