Detailed information NTG0342531

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT44_RS07340
• Genome accession: NZ_CP035455
• Coordinates: 1406391..1408544 (+)
• Length: 717 a.a.
• NCBI ID: WP_136021909.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm197
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1401391..1413544

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT44_RS07290 (ETT44_07280)	stcA	1401510..1401779 (+)	270	WP_023605037.1	quorum-sensing system protein StcA	-
ETT44_RS07295 (ETT44_07285)	-	1402127..1402525 (-)	399	WP_014635342.1	hypothetical protein	-
ETT44_RS07300 (ETT44_07290)	-	1402618..1403689 (-)	1072	Protein_1353	hypothetical protein	-
ETT44_RS07305 (ETT44_07295)	-	1403940..1404341 (-)	402	WP_023605036.1	hypothetical protein	-
ETT44_RS07310 (ETT44_07300)	-	1404535..1404816 (-)	282	WP_136021908.1	hypothetical protein	-
ETT44_RS09565 (ETT44_07305)	-	1404866..1405039 (-)	174	WP_306460903.1	bacteriocin	-
ETT44_RS07325 (ETT44_07315)	-	1405355..1405555 (-)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT44_RS07330 (ETT44_07320)	-	1405568..1405795 (-)	228	WP_012560514.1	Blp family class II bacteriocin	-
ETT44_RS07340 (ETT44_07330)	comA/nlmT	1406391..1408544 (+)	2154	WP_136021909.1	peptide cleavage/export ABC transporter	Regulator
ETT44_RS07345 (ETT44_07335)	-	1408555..1409919 (+)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
ETT44_RS07350 (ETT44_07340)	-	1409996..1410121 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT44_RS07355 (ETT44_07345)	-	1410269..1411603 (-)	1335	WP_014635339.1	sensor histidine kinase	-
ETT44_RS07360 (ETT44_07350)	comE/blpR	1411604..1412353 (-)	750	WP_002992578.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80584.55 Da
• Isoelectric Point: 7.1728

>NTDB_id=342531 ETT44_RS07340 WP_136021909.1 1406391..1408544(+) (comA/nlmT) [Streptococcus pyogenes strain emm197]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPNPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLINFLPL
IFKQRSLIFYIILASLLVTLINIVVSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=342531 ETT44_RS07340 WP_136021909.1 1406391..1408544(+) (comA/nlmT) [Streptococcus pyogenes strain emm197]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGGTTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTAACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAACTTTTTACCTCTT
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGTTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAATTACCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACCAAACTTCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAATTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.727	99.721	0.725
comA	Streptococcus mitis NCTC 12261	67.37	99.163	0.668
comA	Streptococcus pneumoniae Rx1	66.948	99.163	0.664
comA	Streptococcus pneumoniae D39	66.948	99.163	0.664
comA	Streptococcus pneumoniae R6	66.948	99.163	0.664
comA	Streptococcus mitis SK321	66.948	99.163	0.664
comA	Streptococcus pneumoniae TIGR4	66.667	99.163	0.661
comA	Streptococcus gordonii str. Challis substr. CH1	65.874	99.721	0.657