Detailed information NTG0342377

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT46_RS00330
• Genome accession: NZ_CP035453
• Coordinates: 53187..54098 (+)
• Length: 303 a.a.
• NCBI ID: WP_011888526.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm100
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48187..59098

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT46_RS00310 (ETT46_00310)	purE	48457..48948 (+)	492	WP_032464131.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT46_RS00315 (ETT46_00315)	purK	48935..50008 (+)	1074	WP_186789095.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT46_RS00320 (ETT46_00320)	-	50110..51591 (+)	1482	WP_136265276.1	PIN-like domain-containing protein	-
ETT46_RS00325 (ETT46_00325)	purB	51764..53056 (+)	1293	WP_115353931.1	adenylosuccinate lyase	-
ETT46_RS00330 (ETT46_00330)	comR	53187..54098 (+)	912	WP_011888526.1	XRE family transcriptional regulator	Regulator
ETT46_RS09565	comS	54189..54287 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT46_RS00335 (ETT46_00335)	ruvB	54318..55316 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
ETT46_RS00340 (ETT46_00340)	-	55454..55891 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT46_RS00345 (ETT46_00345)	-	55914..56315 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT46_RS00350 (ETT46_00350)	-	56312..58087 (+)	1776	WP_021733211.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=342377 ETT46_RS00330 WP_011888526.1 53187..54098(+) (comR) [Streptococcus pyogenes strain emm100]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=342377 ETT46_RS00330 WP_011888526.1 53187..54098(+) (comR) [Streptococcus pyogenes strain emm100]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.67	100	0.997
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366