Detailed information NTG0341887

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT55_RS00330
• Genome accession: NZ_CP035444
• Coordinates: 52935..53846 (+)
• Length: 303 a.a.
• NCBI ID: WP_136021710.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm90.5
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 47935..58846

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT55_RS00310 (ETT55_00310)	purE	48521..49012 (+)	492	WP_023079042.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT55_RS00315 (ETT55_00315)	purK	48999..50072 (+)	1074	WP_168388917.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT55_RS00320 (ETT55_00320)	-	50074..51492 (+)	1419	WP_011888524.1	hypothetical protein	-
ETT55_RS00325 (ETT55_00325)	purB	51512..52804 (+)	1293	WP_030126529.1	adenylosuccinate lyase	-
ETT55_RS00330 (ETT55_00330)	comR	52935..53846 (+)	912	WP_136021710.1	XRE family transcriptional regulator	Regulator
ETT55_RS08865	comS	53937..54035 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT55_RS00335 (ETT55_00335)	ruvB	54066..55064 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
ETT55_RS00340 (ETT55_00340)	-	55202..55639 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT55_RS00345 (ETT55_00345)	-	55662..56063 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT55_RS00350 (ETT55_00350)	-	56060..57835 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35915.59 Da
• Isoelectric Point: 4.9349

>NTDB_id=341887 ETT55_RS00330 WP_136021710.1 52935..53846(+) (comR) [Streptococcus pyogenes strain emm90.5]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCVDTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=341887 ETT55_RS00330 WP_136021710.1 52935..53846(+) (comR) [Streptococcus pyogenes strain emm90.5]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGTGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.01	100	0.99
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.71	98.02	0.37
comR	Streptococcus suis 05ZYH33	37.71	98.02	0.37