Detailed information NTG0341584

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: ETT61_RS02675
• Genome accession: NZ_CP035438
• Coordinates: 483429..485582 (-)
• Length: 717 a.a.
• NCBI ID: WP_136020169.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm22.8
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 478429..490582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT61_RS02655 (ETT61_02655)	comE/blpR	479620..480369 (+)	750	WP_030126108.1	response regulator transcription factor	Regulator
ETT61_RS02660 (ETT61_02660)	-	480370..481704 (+)	1335	WP_063631787.1	sensor histidine kinase	-
ETT61_RS02665 (ETT61_02665)	-	481852..481977 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
ETT61_RS02670 (ETT61_02670)	-	482054..483418 (-)	1365	WP_136020168.1	bacteriocin secretion accessory protein	-
ETT61_RS02675 (ETT61_02675)	comA/nlmT	483429..485582 (-)	2154	WP_136020169.1	peptide cleavage/export ABC transporter	Regulator
ETT61_RS02685 (ETT61_02685)	-	486174..486401 (+)	228	WP_111713896.1	Blp family class II bacteriocin	-
ETT61_RS02690 (ETT61_02690)	-	486414..486614 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ETT61_RS10520 (ETT61_02700)	-	486930..487103 (+)	174	WP_315940771.1	bacteriocin	-
ETT61_RS02705 (ETT61_02705)	-	487153..487413 (+)	261	WP_136020170.1	hypothetical protein	-
ETT61_RS02710 (ETT61_02710)	-	487629..488030 (+)	402	WP_053308564.1	hypothetical protein	-
ETT61_RS02715 (ETT61_02715)	-	488368..488568 (+)	201	Protein_468	histidine kinase	-
ETT61_RS02720 (ETT61_02720)	stcA	488916..489185 (-)	270	WP_020833327.1	quorum-sensing system protein StcA	-
ETT61_RS10525 (ETT61_02725)	-	489707..489949 (-)	243	WP_002985713.1	hypothetical protein	-
ETT61_RS02730	shp2	490099..490167 (-)	69	WP_128650799.1	peptide pheromone SHP2	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80594.76 Da
• Isoelectric Point: 7.3261

>NTDB_id=341584 ETT61_RS02675 WP_136020169.1 483429..485582(-) (comA/nlmT) [Streptococcus pyogenes strain emm22.8]
MISYRKTFVAQIDAIDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILKQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTNEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLESAKVANNRLNEVYLVKSEFQKEQALTDTYCL
YGDIQFADLSYKYGFGRDTLSDISLTIKEGEKVSIVGINGSGKTTLAKMIVNFFEPYKGQISINHQNLKMIDKKVLRQHI
NYLPQQAYIFSGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=341584 ETT61_RS02675 WP_136020169.1 483429..485582(-) (comA/nlmT) [Streptococcus pyogenes strain emm22.8]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTATAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCAAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAC
GTCATTTTATCTTACATTCGCCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAATGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGGAATCCGCTAAGGTTG
CCAATAATCGGCTTAATGAAGTTTACCTGGTTAAATCTGAGTTCCAAAAAGAACAGGCATTAACAGATACCTATTGTCTA
TATGGAGATATCCAATTTGCAGACTTGTCTTATAAATACGGCTTTGGTCGTGATACCTTATCTGATATCAGTTTGACCAT
TAAGGAGGGTGAAAAAGTCAGTATAGTTGGTATTAATGGTTCTGGCAAGACAACATTAGCTAAAATGATTGTTAATTTCT
TTGAACCTTACAAGGGACAGATTTCTATTAATCATCAAAATCTTAAAATGATTGATAAAAAAGTACTTCGTCAGCATATC
AACTATCTCCCCCAACAAGCTTATATCTTTAGTGGATCTATCTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (168-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	71.888	99.721	0.717
comA	Streptococcus mitis NCTC 12261	66.807	99.582	0.665
comA	Streptococcus mitis SK321	66.387	99.582	0.661
comA	Streptococcus pneumoniae Rx1	66.387	99.582	0.661
comA	Streptococcus pneumoniae D39	66.387	99.582	0.661
comA	Streptococcus pneumoniae R6	66.387	99.582	0.661
comA	Streptococcus pneumoniae TIGR4	66.106	99.582	0.658
comA	Streptococcus gordonii str. Challis substr. CH1	65.46	100	0.656