Detailed information NTG0341562

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT61_RS00340
• Genome accession: NZ_CP035438
• Coordinates: 53301..54203 (+)
• Length: 300 a.a.
• NCBI ID: WP_032460886.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm22.8
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48301..59203

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT61_RS00310 (ETT61_00310)	purE	48462..48953 (+)	492	WP_136020477.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT61_RS00315 (ETT61_00315)	purK	48940..50013 (+)	1074	WP_168389649.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT61_RS10260	-	50014..50448 (+)	435	WP_247275531.1	hypothetical protein	-
ETT61_RS10265	-	50576..50935 (+)	360	WP_229380364.1	hypothetical protein	-
ETT61_RS00325 (ETT61_00325)	-	50948..51517 (+)	570	WP_032460531.1	hypothetical protein	-
ETT61_RS00330 (ETT61_00330)	-	51521..51883 (+)	363	WP_136020475.1	hypothetical protein	-
ETT61_RS00335 (ETT61_00335)	purB	51880..53172 (+)	1293	WP_136020474.1	adenylosuccinate lyase	-
ETT61_RS00340 (ETT61_00340)	comR	53301..54203 (+)	903	WP_032460886.1	transcriptional regulator Rgg4/ComR	Regulator
ETT61_RS10475	comS	54287..54382 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ETT61_RS00345 (ETT61_00345)	ruvB	54429..55427 (+)	999	WP_136020473.1	Holliday junction branch migration DNA helicase RuvB	-
ETT61_RS00350 (ETT61_00350)	-	55565..56002 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT61_RS00355 (ETT61_00355)	-	56025..56426 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
ETT61_RS00360 (ETT61_00360)	-	56423..58198 (+)	1776	WP_136020472.1	acyltransferase family protein	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35352.85 Da
• Isoelectric Point: 4.5164

>NTDB_id=341562 ETT61_RS00340 WP_032460886.1 53301..54203(+) (comR) [Streptococcus pyogenes strain emm22.8]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMAKIQ
DWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 903 bp

>NTDB_id=341562 ETT61_RS00340 WP_032460886.1 53301..54203(+) (comR) [Streptococcus pyogenes strain emm22.8]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTGATATTTCAT
CACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCGAAAATTCAA
GATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAATAAAAGCAGA
ACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTCAAGAGTGGG
AAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-293)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.01	100	1
comR	Streptococcus pyogenes MGAS315	58.472	100	0.587
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.546	97	0.5
comR	Streptococcus mutans UA159	46.358	100	0.467