Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   ETT64_RS00330 Genome accession   NZ_CP035435
Coordinates   53457..54368 (+) Length   303 a.a.
NCBI ID   WP_020904818.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm64.3     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 48457..59368
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT64_RS00315 (ETT64_00315) purK 48829..49902 (+) 1074 WP_063632455.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  ETT64_RS00320 (ETT64_00320) - 49918..51726 (+) 1809 WP_038432716.1 ATP-binding protein -
  ETT64_RS00325 (ETT64_00325) purB 52034..53326 (+) 1293 WP_136275745.1 adenylosuccinate lyase -
  ETT64_RS00330 (ETT64_00330) comR 53457..54368 (+) 912 WP_020904818.1 XRE family transcriptional regulator Regulator
  ETT64_RS09240 comS 54459..54557 (+) 99 WP_020833188.1 quorum-sensing system DWW-type pheromone Regulator
  ETT64_RS00335 (ETT64_00335) ruvB 54588..55586 (+) 999 WP_002986679.1 Holliday junction branch migration DNA helicase RuvB -
  ETT64_RS00340 (ETT64_00340) - 55724..56161 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  ETT64_RS00345 (ETT64_00345) - 56184..56585 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  ETT64_RS00350 (ETT64_00350) - 56582..58357 (+) 1776 WP_136026532.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35887.54 Da        Isoelectric Point: 4.9349

>NTDB_id=341405 ETT64_RS00330 WP_020904818.1 53457..54368(+) (comR) [Streptococcus pyogenes strain emm64.3]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDAQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide


Download         Length: 912 bp        

>NTDB_id=341405 ETT64_RS00330 WP_020904818.1 53457..54368(+) (comR) [Streptococcus pyogenes strain emm64.3]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGCACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

99.34

100

0.993
  comR Streptococcus pyogenes MGAS8232

58.472

99.34

0.581
  comR Streptococcus mutans UA159

47.157

98.68

0.465
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

46.441

97.36

0.452
  comR Streptococcus suis P1/7

37.374

98.02

0.366
  comR Streptococcus suis 05ZYH33

37.374

98.02

0.366

Multiple sequence alignment