Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   ETT66_RS00290 Genome accession   NZ_CP035433
Coordinates   50591..51502 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emm65     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 45591..56502
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT66_RS00275 (ETT66_00275) - 47434..48546 (+) 1113 WP_168665103.1 DUF262 domain-containing protein -
  ETT66_RS00280 (ETT66_00280) - 48550..49158 (+) 609 WP_032464127.1 hypothetical protein -
  ETT66_RS00285 (ETT66_00285) purB 49168..50460 (+) 1293 WP_136286590.1 adenylosuccinate lyase -
  ETT66_RS00290 (ETT66_00290) comR 50591..51502 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  ETT66_RS09280 comS 51586..51681 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  ETT66_RS00295 (ETT66_00295) ruvB 51728..52726 (+) 999 WP_136286592.1 Holliday junction branch migration DNA helicase RuvB -
  ETT66_RS00300 (ETT66_00300) - 52864..53301 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  ETT66_RS00305 (ETT66_00305) - 53324..53725 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  ETT66_RS00310 (ETT66_00310) - 53722..55497 (+) 1776 WP_136286594.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=341299 ETT66_RS00290 WP_002986681.1 50591..51502(+) (comR) [Streptococcus pyogenes strain emm65]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=341299 ETT66_RS00290 WP_002986681.1 50591..51502(+) (comR) [Streptococcus pyogenes strain emm65]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment