Detailed information NTG0341195

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT68_RS00330
• Genome accession: NZ_CP035431
• Coordinates: 53055..53966 (+)
• Length: 303 a.a.
• NCBI ID: WP_136275697.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm105
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48055..58966

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT68_RS00310 (ETT68_00310)	purE	48350..48841 (+)	492	WP_136275695.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT68_RS00315 (ETT68_00315)	purK	48828..49901 (+)	1074	WP_168435463.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT68_RS00320 (ETT68_00320)	-	49922..51262 (+)	1341	WP_136099258.1	hypothetical protein	-
ETT68_RS00325 (ETT68_00325)	purB	51631..52923 (+)	1293	WP_136099259.1	adenylosuccinate lyase	-
ETT68_RS00330 (ETT68_00330)	comR	53055..53966 (+)	912	WP_136275697.1	XRE family transcriptional regulator	Regulator
ETT68_RS09115	comS	54057..54155 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
ETT68_RS00335 (ETT68_00335)	ruvB	54186..55184 (+)	999	WP_014407198.1	Holliday junction branch migration DNA helicase RuvB	-
ETT68_RS00340 (ETT68_00340)	-	55322..55759 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ETT68_RS00345 (ETT68_00345)	-	55782..56183 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
ETT68_RS00350 (ETT68_00350)	-	56180..57955 (+)	1776	WP_136099260.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35973.63 Da
• Isoelectric Point: 4.8568

>NTDB_id=341195 ETT68_RS00330 WP_136275697.1 53055..53966(+) (comR) [Streptococcus pyogenes strain emm105]
MLEHFDGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=341195 ETT68_RS00330 WP_136275697.1 53055..53966(+) (comR) [Streptococcus pyogenes strain emm105]
ATGTTAGAACATTTTGATGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.14	99.34	0.578
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.037	98.02	0.363
comR	Streptococcus suis 05ZYH33	37.037	98.02	0.363