Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   ETT70_RS02385 Genome accession   NZ_CP035429
Coordinates   432926..433636 (+) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain emmNA     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 427926..438636
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ETT70_RS02360 (ETT70_02355) - 427936..428649 (+) 714 WP_301182272.1 MIP/aquaporin family protein -
  ETT70_RS02365 (ETT70_02360) - 428784..429353 (+) 570 WP_136020185.1 hypothetical protein -
  ETT70_RS02370 (ETT70_02365) - 429322..430470 (+) 1149 WP_136275789.1 acetyl-CoA C-acyltransferase -
  ETT70_RS02375 (ETT70_02370) - 430427..431674 (+) 1248 WP_136269207.1 AMP-binding protein -
  ETT70_RS02380 (ETT70_02375) - 431730..432764 (+) 1035 WP_186787901.1 DUF3114 domain-containing protein -
  ETT70_RS02385 (ETT70_02380) vicR 432926..433636 (+) 711 WP_002985645.1 response regulator YycF Regulator
  ETT70_RS02390 (ETT70_02385) vicK 433629..434981 (+) 1353 WP_002995609.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ETT70_RS02395 (ETT70_02390) vicX 434985..435794 (+) 810 WP_002985641.1 MBL fold metallo-hydrolase Regulator
  ETT70_RS02400 (ETT70_02395) rnc 436237..436929 (+) 693 WP_002990670.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=341108 ETT70_RS02385 WP_002985645.1 432926..433636(+) (vicR) [Streptococcus pyogenes strain emmNA]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=341108 ETT70_RS02385 WP_002985645.1 432926..433636(+) (vicR) [Streptococcus pyogenes strain emmNA]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCGCGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTTCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364

Multiple sequence alignment