Detailed information NTG0340922

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ETT73_RS00395
• Genome accession: NZ_CP035426
• Coordinates: 59236..60147 (+)
• Length: 303 a.a.
• NCBI ID: WP_023611326.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain emm57
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 54236..65147

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ETT73_RS00375 (ETT73_00375)	purE	54532..55023 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ETT73_RS00380 (ETT73_00380)	purK	55010..56083 (+)	1074	WP_168640767.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ETT73_RS00385 (ETT73_00385)	-	56104..57444 (+)	1341	WP_023611329.1	hypothetical protein	-
ETT73_RS00390 (ETT73_00390)	purB	57813..59105 (+)	1293	WP_136098009.1	adenylosuccinate lyase	-
ETT73_RS00395 (ETT73_00395)	comR	59236..60147 (+)	912	WP_023611326.1	transcriptional regulator Rgg4/ComR	Regulator
ETT73_RS09140	comS	60231..60326 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ETT73_RS00400 (ETT73_00400)	ruvB	60373..61371 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ETT73_RS00405 (ETT73_00405)	-	61509..61946 (+)	438	WP_136112731.1	low molecular weight protein-tyrosine-phosphatase	-
ETT73_RS00410 (ETT73_00410)	-	61969..62370 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
ETT73_RS00415 (ETT73_00415)	-	62367..64142 (+)	1776	WP_136276804.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35685.21 Da
• Isoelectric Point: 4.5164

>NTDB_id=340922 ETT73_RS00395 WP_023611326.1 59236..60147(+) (comR) [Streptococcus pyogenes strain emm57]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSGQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=340922 ETT73_RS00395 WP_023611326.1 59236..60147(+) (comR) [Streptococcus pyogenes strain emm57]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGGACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462