Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   FOB78_RS11480 Genome accession   NZ_CP044090
Coordinates   2160788..2161462 (+) Length   224 a.a.
NCBI ID   WP_001238594.1    Uniprot ID   P0A4I0
Organism   Streptococcus agalactiae strain FDAARGOS_670     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2155788..2166462
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOB78_RS11465 (FOB78_11465) - 2157361..2158527 (-) 1167 WP_000160532.1 IS30-like element ISSag9 family transposase -
  FOB78_RS11470 (FOB78_11470) - 2158759..2160114 (+) 1356 WP_000712231.1 YjiH family protein -
  FOB78_RS11475 (FOB78_11475) rpmH 2160298..2160432 (+) 135 WP_000831903.1 50S ribosomal protein L34 -
  FOB78_RS11480 (FOB78_11480) ciaR 2160788..2161462 (+) 675 WP_001238594.1 two-component system response regulator DltR Regulator
  FOB78_RS11485 (FOB78_11485) dltS 2161462..2162649 (+) 1188 WP_000490535.1 two-component system sensor histidine kinase DltS -
  FOB78_RS11490 (FOB78_11490) dltX 2162660..2162782 (+) 123 WP_000806142.1 teichoic acid D-Ala incorporation-associated protein DltX -
  FOB78_RS11495 (FOB78_11495) dltA 2162795..2164330 (+) 1536 WP_000581010.1 D-alanine--poly(phosphoribitol) ligase subunit DltA -
  FOB78_RS11500 (FOB78_11500) dltB 2164327..2165592 (+) 1266 WP_150352961.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -
  FOB78_RS11505 (FOB78_11505) dltC 2165607..2165846 (+) 240 WP_000351975.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25504.44 Da        Isoelectric Point: 5.4971

>NTDB_id=340331 FOB78_RS11480 WP_001238594.1 2160788..2161462(+) (ciaR) [Streptococcus agalactiae strain FDAARGOS_670]
MRLLVVEDEKSIAEAIQALLADKGYSVDLAFDGDDGLEYILTGLYDLVLLDIMLPKRSGLSVLKRVREAGLETPIIFLTA
KSQTYDKVNGLDLGADDYITKPFEADELLARIRLRTRQSSLIRANQLRLGNIRLNTDSHELESKESSVKLSNKEFLLMEV
FMRNAKQIIPKNQLISKVWGPSDNSEYNQLEVFISFLRKKLRFLKADIEIITTKGFGYSLEERT

Nucleotide


Download         Length: 675 bp        

>NTDB_id=340331 FOB78_RS11480 WP_001238594.1 2160788..2161462(+) (ciaR) [Streptococcus agalactiae strain FDAARGOS_670]
ATGAGACTTCTTGTAGTTGAGGATGAAAAAAGTATAGCAGAGGCTATTCAGGCTTTATTGGCAGATAAAGGTTATTCTGT
TGATTTAGCATTTGATGGAGATGATGGGTTAGAATACATTTTGACAGGTCTCTATGATTTAGTCCTGTTGGATATTATGT
TACCCAAACGCTCAGGATTATCTGTTTTAAAAAGAGTGAGGGAAGCTGGTTTAGAAACCCCAATAATCTTTTTAACTGCA
AAATCACAGACTTATGATAAAGTTAATGGTTTAGATTTAGGGGCAGATGATTATATCACAAAACCCTTTGAAGCAGATGA
ATTGCTAGCTAGAATTAGGCTGAGAACCAGACAATCTTCTCTAATCAGAGCAAATCAATTGCGGCTTGGAAATATAAGGC
TTAACACAGATTCACATGAGCTAGAATCTAAAGAAAGTAGTGTAAAATTATCCAATAAAGAATTTCTCTTGATGGAAGTT
TTTATGCGAAATGCAAAGCAGATTATTCCTAAAAATCAGTTGATTTCTAAGGTTTGGGGACCTTCAGACAATTCAGAATA
TAACCAGTTAGAAGTATTTATTTCTTTTTTGCGAAAAAAATTGCGCTTTTTAAAAGCAGACATTGAAATAATAACCACTA
AGGGCTTTGGATATTCCTTGGAGGAGAGGACATAA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A4I0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

37.838

99.107

0.375
  ciaR Streptococcus pneumoniae Rx1

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae D39

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae TIGR4

37.387

99.107

0.371
  ciaR Streptococcus pneumoniae R6

37.387

99.107

0.371
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366
  covR Streptococcus salivarius strain HSISS4

35.371

100

0.362

Multiple sequence alignment