Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ESP48_RS06760 Genome accession   NZ_CP035306
Coordinates   1247851..1248540 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain IDCC2201     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1242851..1253540
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ESP48_RS10220 (ESP48_06735) - 1243818..1243988 (+) 171 Protein_1239 ascorbate 6-phosphate lactonase -
  ESP48_RS06740 (ESP48_06740) - 1244005..1244676 (-) 672 WP_064355629.1 potassium channel family protein -
  ESP48_RS06745 (ESP48_06745) - 1244716..1246080 (-) 1365 WP_081247984.1 TrkH family potassium uptake protein -
  ESP48_RS06750 (ESP48_06750) rsmG 1246150..1246863 (-) 714 WP_064355625.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ESP48_RS06755 (ESP48_06755) - 1247159..1247695 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  ESP48_RS06760 (ESP48_06760) covR 1247851..1248540 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  ESP48_RS06765 (ESP48_06765) covS 1248537..1250054 (+) 1518 WP_002949640.1 HAMP domain-containing sensor histidine kinase Regulator
  ESP48_RS06770 (ESP48_06770) nrdR 1250176..1250655 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  ESP48_RS06775 (ESP48_06775) - 1250652..1251827 (+) 1176 WP_011680739.1 DnaD domain protein -
  ESP48_RS06780 (ESP48_06780) dnaI 1251831..1252733 (+) 903 WP_011680740.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=339191 ESP48_RS06760 WP_002949638.1 1247851..1248540(+) (covR) [Streptococcus thermophilus strain IDCC2201]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=339191 ESP48_RS06760 WP_002949638.1 1247851..1248540(+) (covR) [Streptococcus thermophilus strain IDCC2201]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACTTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment