Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   ESP48_RS06765 Genome accession   NZ_CP035306
Coordinates   1248537..1250054 (+) Length   505 a.a.
NCBI ID   WP_002949640.1    Uniprot ID   A0A060BQ50
Organism   Streptococcus thermophilus strain IDCC2201     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1243537..1255054
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ESP48_RS10220 (ESP48_06735) - 1243818..1243988 (+) 171 Protein_1239 ascorbate 6-phosphate lactonase -
  ESP48_RS06740 (ESP48_06740) - 1244005..1244676 (-) 672 WP_064355629.1 potassium channel family protein -
  ESP48_RS06745 (ESP48_06745) - 1244716..1246080 (-) 1365 WP_081247984.1 TrkH family potassium uptake protein -
  ESP48_RS06750 (ESP48_06750) rsmG 1246150..1246863 (-) 714 WP_064355625.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ESP48_RS06755 (ESP48_06755) - 1247159..1247695 (+) 537 WP_002946488.1 DUF177 domain-containing protein -
  ESP48_RS06760 (ESP48_06760) covR 1247851..1248540 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  ESP48_RS06765 (ESP48_06765) covS 1248537..1250054 (+) 1518 WP_002949640.1 HAMP domain-containing sensor histidine kinase Regulator
  ESP48_RS06770 (ESP48_06770) nrdR 1250176..1250655 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  ESP48_RS06775 (ESP48_06775) - 1250652..1251827 (+) 1176 WP_011680739.1 DnaD domain protein -
  ESP48_RS06780 (ESP48_06780) dnaI 1251831..1252733 (+) 903 WP_011680740.1 primosomal protein DnaI -
  ESP48_RS06785 (ESP48_06785) der 1252839..1254149 (+) 1311 WP_064355621.1 ribosome biogenesis GTPase Der -
  ESP48_RS09890 - 1254213..1254882 (+) 670 Protein_1250 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57536.93 Da        Isoelectric Point: 5.2689

>NTDB_id=339192 ESP48_RS06765 WP_002949640.1 1248537..1250054(+) (covS) [Streptococcus thermophilus strain IDCC2201]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=339192 ESP48_RS06765 WP_002949640.1 1248537..1250054(+) (covS) [Streptococcus thermophilus strain IDCC2201]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

ArlS sensor domain (ArlS_N)

(39-187)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BQ50

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.622

99.406

0.941

Multiple sequence alignment