Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EQH15_RS06130 Genome accession   NZ_CP035265
Coordinates   1220839..1221576 (-) Length   245 a.a.
NCBI ID   WP_000782666.1    Uniprot ID   A0A0B7LTB2
Organism   Streptococcus pneumoniae strain TVO_1901920     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1215839..1226576
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH15_RS06110 (EQH15_06415) msrB 1217072..1218010 (-) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EQH15_RS06115 (EQH15_06420) - 1218039..1218455 (-) 417 WP_001857510.1 hypothetical protein -
  EQH15_RS06120 (EQH15_06425) thrB 1218531..1219400 (-) 870 WP_000692438.1 homoserine kinase -
  EQH15_RS06125 (EQH15_06430) - 1219402..1220688 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  EQH15_RS06130 (EQH15_06435) mecA 1220839..1221576 (-) 738 WP_000782666.1 adaptor protein MecA Regulator
  EQH15_RS06135 (EQH15_06440) - 1221718..1222752 (-) 1035 WP_238102255.1 prephenate dehydratase -
  EQH15_RS06140 (EQH15_06445) - 1222781..1224214 (-) 1434 WP_000565088.1 O-antigen polysaccharide polymerase Wzy family protein -
  EQH15_RS06145 (EQH15_06450) - 1224230..1225216 (-) 987 WP_000446981.1 glycosyltransferase family 2 protein -
  EQH15_RS06150 (EQH15_06455) - 1225218..1226321 (-) 1104 WP_000225892.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28391.16 Da        Isoelectric Point: 4.0199

>NTDB_id=338695 EQH15_RS06130 WP_000782666.1 1220839..1221576(-) (mecA) [Streptococcus pneumoniae strain TVO_1901920]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFARTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=338695 EQH15_RS06130 WP_000782666.1 1220839..1221576(-) (mecA) [Streptococcus pneumoniae strain TVO_1901920]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAGGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LTB2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment