Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EQH18_RS02375 Genome accession   NZ_CP035262
Coordinates   474886..475623 (+) Length   245 a.a.
NCBI ID   WP_001219146.1    Uniprot ID   A0A1C0UQ30
Organism   Streptococcus pneumoniae strain TVO_1901923     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 469886..480623
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH18_RS02345 (EQH18_02500) - 471217..471504 (-) 288 WP_000777760.1 hypothetical protein -
  EQH18_RS02350 (EQH18_02505) - 471514..471924 (-) 411 WP_001278301.1 HIT family protein -
  EQH18_RS02355 (EQH18_02510) pptA 471992..472723 (+) 732 WP_000889924.1 ABC transporter ATP-binding protein Regulator
  EQH18_RS02360 (EQH18_02515) - 472720..473769 (+) 1050 WP_000653779.1 ABC transporter permease -
  EQH18_RS02365 (EQH18_02520) - 473937..474266 (-) 330 WP_000132572.1 hypothetical protein -
  EQH18_RS02370 (EQH18_02525) - 474543..474881 (+) 339 WP_000682132.1 LytTR family DNA-binding domain-containing protein -
  EQH18_RS02375 (EQH18_02530) comE/blpR 474886..475623 (+) 738 WP_001219146.1 response regulator transcription factor Regulator
  EQH18_RS02380 (EQH18_02535) - 475637..476977 (+) 1341 WP_001099895.1 sensor histidine kinase -
  EQH18_RS02385 (EQH18_02540) blpC 477022..477177 (-) 156 WP_000358814.1 quorum-sensing system pheromone BlpC -
  EQH18_RS02390 (EQH18_02545) - 477234..478595 (-) 1362 WP_061375123.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28768.87 Da        Isoelectric Point: 6.0454

>NTDB_id=338445 EQH18_RS02375 WP_001219146.1 474886..475623(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901923]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=338445 EQH18_RS02375 WP_001219146.1 474886..475623(+) (comE/blpR) [Streptococcus pneumoniae strain TVO_1901923]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1C0UQ30

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363

Multiple sequence alignment