Detailed information NTG0338121

Bioinformatically predicted

Overview

• Name: radC
• Type: Machinery gene
• Locus tag: MGAS2221_RS04340
• Genome accession: NZ_CP043530
• Coordinates: 857788..858468 (+)
• Length: 226 a.a.
• NCBI ID: WP_002984709.1
• Uniprot ID: A2REK0
• Organism: Streptococcus pyogenes strain MGAS2221
• Function: homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 852788..863468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS2221_RS04320 (MGAS2221_0855)	aphA	853214..853945 (+)	732	WP_002984720.1	acid phosphatase AphA	-
MGAS2221_RS04325 (MGAS2221_0856)	-	854123..855655 (+)	1533	WP_010922291.1	ClC family H(+)/Cl(-) exchange transporter	-
MGAS2221_RS04330 (MGAS2221_0857)	-	855818..856432 (+)	615	WP_010922292.1	SGNH/GDSL hydrolase family protein	-
MGAS2221_RS04335 (MGAS2221_0858)	-	856612..857739 (+)	1128	WP_002994399.1	AI-2E family transporter	-
MGAS2221_RS04340 (MGAS2221_0859)	radC	857788..858468 (+)	681	WP_002984709.1	DNA repair protein RadC	Machinery gene
MGAS2221_RS04345 (MGAS2221_0860)	-	858470..859165 (-)	696	WP_002989835.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
MGAS2221_RS04350 (MGAS2221_0861)	-	859175..859819 (-)	645	WP_002984705.1	redox-sensing transcriptional repressor Rex	-
MGAS2221_RS04355 (MGAS2221_0862)	-	860071..860418 (-)	348	WP_002989831.1	DUF1831 domain-containing protein	-
MGAS2221_RS04360 (MGAS2221_0863)	-	860408..861535 (-)	1128	WP_002989829.1	cysteine desulfurase family protein	-
MGAS2221_RS04365 (MGAS2221_0864)	-	861532..862512 (-)	981	WP_010922293.1	ribose-phosphate diphosphokinase	-
MGAS2221_RS04370 (MGAS2221_0865)	-	862652..863230 (-)	579	WP_002984698.1	CYTH domain-containing protein	-

Sequence

Protein

• Length: 226 a.a.
• Molecular weight: 25742.96 Da
• Isoelectric Point: 7.3866

>NTDB_id=338121 MGAS2221_RS04340 WP_002984709.1 857788..858468(+) (radC) [Streptococcus pyogenes strain MGAS2221]
MYSIKCDDNKAMPRERLMRLGAESLSNQELLAILLRTGNKEKHVLELSSYLLSHLDSLADFKKMSLQELQHLAGIGKVKA
IEIKAMIELVSRILATDKTLTDSVLTSVQVAEKMMAALGDKKQEHLVVLYLDNQNRIIEEKTIFIGTVRRSLAEPREILY
YACKNMATSLIVIHNHPSGNIEPSSNDYCFTEKIKRSCEDLGIICLDHIIVSYKDYYSFREKSTLF

Nucleotide

• Length: 681 bp

>NTDB_id=338121 MGAS2221_RS04340 WP_002984709.1 857788..858468(+) (radC) [Streptococcus pyogenes strain MGAS2221]
ATGTATTCTATAAAATGTGATGATAATAAAGCCATGCCAAGAGAACGTTTGATGCGACTAGGAGCAGAGTCTCTAAGTAA
TCAAGAATTATTAGCAATTTTATTACGAACAGGTAATAAAGAAAAGCATGTCTTAGAGCTGTCATCCTATCTTTTATCGC
ATTTAGACAGTCTGGCAGATTTTAAAAAGATGTCTTTGCAAGAATTACAACATTTGGCAGGTATAGGAAAAGTTAAAGCG
ATTGAAATTAAAGCTATGATTGAGTTGGTTTCCCGAATTTTAGCGACAGATAAGACATTAACTGATAGCGTATTAACCAG
TGTTCAGGTCGCTGAAAAAATGATGGCAGCTTTAGGAGATAAAAAACAAGAGCATTTAGTCGTATTGTATTTAGATAATC
AAAATCGTATTATTGAAGAAAAAACTATTTTTATTGGGACTGTCCGACGTTCACTTGCAGAACCAAGAGAAATTTTATAC
TATGCCTGTAAAAATATGGCGACTAGTCTCATTGTTATTCATAATCATCCTTCAGGAAATATTGAACCTAGTTCTAACGA
TTATTGCTTTACTGAAAAAATAAAACGATCATGTGAAGATTTAGGCATTATCTGTCTAGATCACATTATCGTTAGCTATA
AAGATTATTATAGTTTTCGAGAAAAATCAACCCTTTTTTAA

Domains

Predicted by InterProScan.

• RadC-like JAB domain (RadC) (107-222)

• UPF0758 N-terminal (UPF0758_N) (10-81)

3D structure

• AlphaFold DB: A2REK0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
radC	Streptococcus pneumoniae TIGR4	57.965	100	0.58
radC	Streptococcus pneumoniae R6	57.522	100	0.575
radC	Streptococcus pneumoniae D39	57.522	100	0.575
radC	Streptococcus gordonii str. Challis substr. CH1	55.752	100	0.558
ysxA/radC	Bacillus subtilis subsp. subtilis str. 168	43.119	96.46	0.416
radC	Haemophilus influenzae Rd KW20	37.9	96.903	0.367