Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EQH32_RS06335 Genome accession   NZ_CP035248
Coordinates   1245763..1246500 (-) Length   245 a.a.
NCBI ID   WP_000782673.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901939     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1240763..1251500
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH32_RS06315 (EQH32_06605) msrB 1242222..1243160 (-) 939 WP_238094663.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EQH32_RS06320 - 1243227..1243379 (-) 153 WP_025172527.1 hypothetical protein -
  EQH32_RS06325 (EQH32_06615) thrB 1243455..1244324 (-) 870 WP_000692437.1 homoserine kinase -
  EQH32_RS06330 (EQH32_06620) - 1244326..1245612 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  EQH32_RS06335 (EQH32_06625) mecA 1245763..1246500 (-) 738 WP_000782673.1 adaptor protein MecA Regulator
  EQH32_RS06340 (EQH32_06630) - 1246700..1247734 (-) 1035 WP_000461502.1 hypothetical protein -
  EQH32_RS06345 (EQH32_06635) - 1247763..1249196 (-) 1434 WP_000565081.1 O-antigen polysaccharide polymerase Wzy family protein -
  EQH32_RS06350 (EQH32_06640) - 1249212..1250198 (-) 987 WP_000446966.1 glycosyltransferase family 2 protein -
  EQH32_RS06355 (EQH32_06645) - 1250200..1251303 (-) 1104 WP_000225878.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28415.20 Da        Isoelectric Point: 4.0199

>NTDB_id=337593 EQH32_RS06335 WP_000782673.1 1245763..1246500(-) (mecA) [Streptococcus pneumoniae strain TVO_1901939]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSFEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=337593 EQH32_RS06335 WP_000782673.1 1245763..1246500(-) (mecA) [Streptococcus pneumoniae strain TVO_1901939]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTTTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.39

100

0.482
  mecA Streptococcus thermophilus LMG 18311

46.988

100

0.478
  mecA Streptococcus mutans UA159

47.755

100

0.478

Multiple sequence alignment