Detailed information NTG0337370

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: EQH35_RS08290
• Genome accession: NZ_CP035245
• Coordinates: 1613977..1614636 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565024.1
• Uniprot ID: A0A4J1XTA1
• Organism: Streptococcus pneumoniae strain TVO_1901943
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1608977..1619636

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH35_RS08265 (EQH35_08715)	-	1609282..1609599 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
EQH35_RS08270 (EQH35_08720)	-	1609614..1610510 (-)	897	WP_000825665.1	PEP phosphonomutase	-
EQH35_RS08275 (EQH35_08725)	-	1610513..1611775 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
EQH35_RS08280 (EQH35_08730)	-	1612055..1613233 (+)	1179	WP_000175878.1	ROK family transcriptional regulator	-
EQH35_RS08285 (EQH35_08735)	-	1613461..1613907 (-)	447	WP_000155412.1	GNAT family N-acetyltransferase	-
EQH35_RS08290 (EQH35_08740)	cclA/cilC	1613977..1614636 (+)	660	WP_000565024.1	A24 family peptidase	Machinery gene
EQH35_RS08295 (EQH35_08745)	-	1614688..1615839 (-)	1152	WP_000481758.1	XRE family transcriptional regulator	-
EQH35_RS08300 (EQH35_08750)	-	1615854..1616585 (-)	732	WP_000934017.1	hypothetical protein	-
EQH35_RS08305 (EQH35_08755)	-	1616811..1616915 (+)	105	Protein_1666	prepilin peptidase	-
EQH35_RS08310 (EQH35_08760)	trpA	1616887..1617663 (-)	777	WP_001127028.1	tryptophan synthase subunit alpha	-
EQH35_RS08315 (EQH35_08765)	trpB	1617656..1618879 (-)	1224	WP_000331297.1	tryptophan synthase subunit beta	-
EQH35_RS08320 (EQH35_08770)	-	1618857..1619456 (-)	600	WP_000169899.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24951.16 Da
• Isoelectric Point: 8.2409

>NTDB_id=337370 EQH35_RS08290 WP_000565024.1 1613977..1614636(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901943]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=337370 EQH35_RS08290 WP_000565024.1 1613977..1614636(+) (cclA/cilC) [Streptococcus pneumoniae strain TVO_1901943]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A4J1XTA1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae D39	95.434	100	0.954
cclA/cilC	Streptococcus pneumoniae R6	95.434	100	0.954
cclA/cilC	Streptococcus mitis SK321	91.324	100	0.913
cclA/cilC	Streptococcus mitis NCTC 12261	85.388	100	0.854