Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   EQH35_RS05720 Genome accession   NZ_CP035245
Coordinates   1122260..1122964 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain TVO_1901943     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1117260..1127964
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH35_RS05690 (EQH35_06010) - 1117440..1118426 (+) 987 WP_000204733.1 L-lactate dehydrogenase -
  EQH35_RS05695 (EQH35_06015) - 1118727..1119471 (-) 745 Protein_1147 potassium channel family protein -
  EQH35_RS05700 (EQH35_06020) - 1119518..1119772 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin -
  EQH35_RS05705 (EQH35_06025) relB 1119774..1120016 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  EQH35_RS05710 (EQH35_06030) vicX 1120107..1120916 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  EQH35_RS05715 (EQH35_06035) micB 1120918..1122267 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EQH35_RS05720 (EQH35_06040) micA 1122260..1122964 (-) 705 WP_000722076.1 response regulator YycF Regulator
  EQH35_RS05725 (EQH35_06045) mutY 1123019..1124194 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  EQH35_RS05730 (EQH35_06055) - 1124523..1126193 (-) 1671 WP_000845287.1 formate--tetrahydrofolate ligase -
  EQH35_RS05735 (EQH35_06060) coaB 1126423..1127112 (+) 690 WP_000699489.1 phosphopantothenate--cysteine ligase -
  EQH35_RS05740 (EQH35_06065) coaC 1127124..1127675 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=337359 EQH35_RS05720 WP_000722076.1 1122260..1122964(-) (micA) [Streptococcus pneumoniae strain TVO_1901943]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=337359 EQH35_RS05720 WP_000722076.1 1122260..1122964(-) (micA) [Streptococcus pneumoniae strain TVO_1901943]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment