Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   EQH37_RS10780 Genome accession   NZ_CP035243
Coordinates   2137932..2138057 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain TVO_1901946     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2132932..2143057
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH37_RS10750 - 2133271..2134873 (-) 1603 Protein_2108 YhgE/Pip family protein -
  EQH37_RS10755 (EQH37_11370) - 2135052..2135594 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQH37_RS10770 (EQH37_11385) comE 2135837..2136589 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  EQH37_RS10775 (EQH37_11390) comD/comD2 2136586..2137911 (-) 1326 WP_000364845.1 competence system sensor histidine kinase ComD Regulator
  EQH37_RS10780 (EQH37_11395) comC/comC2 2137932..2138057 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  EQH37_RS10790 (EQH37_11405) rlmH 2138339..2138818 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH37_RS10795 (EQH37_11410) htrA 2139001..2140182 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  EQH37_RS10800 (EQH37_11415) spo0J 2140240..2140998 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=337254 EQH37_RS10780 WP_000799686.1 2137932..2138057(-) (comC/comC2) [Streptococcus pneumoniae strain TVO_1901946]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=337254 EQH37_RS10780 WP_000799686.1 2137932..2138057(-) (comC/comC2) [Streptococcus pneumoniae strain TVO_1901946]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561

Multiple sequence alignment