Detailed information NTG0337252

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH37_RS10770
• Genome accession: NZ_CP035243
• Coordinates: 2135837..2136589 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901946
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2130837..2141589

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH37_RS10750	-	2133271..2134873 (-)	1603	Protein_2108	YhgE/Pip family protein	-
EQH37_RS10755 (EQH37_11370)	-	2135052..2135594 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH37_RS10770 (EQH37_11385)	comE	2135837..2136589 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH37_RS10775 (EQH37_11390)	comD/comD2	2136586..2137911 (-)	1326	WP_000364845.1	competence system sensor histidine kinase ComD	Regulator
EQH37_RS10780 (EQH37_11395)	comC/comC2	2137932..2138057 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
EQH37_RS10790 (EQH37_11405)	rlmH	2138339..2138818 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH37_RS10795 (EQH37_11410)	htrA	2139001..2140182 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH37_RS10800 (EQH37_11415)	spo0J	2140240..2140998 (+)	759	WP_000410378.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=337252 EQH37_RS10770 WP_000866065.1 2135837..2136589(-) (comE) [Streptococcus pneumoniae strain TVO_1901946]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=337252 EQH37_RS10770 WP_000866065.1 2135837..2136589(-) (comE) [Streptococcus pneumoniae strain TVO_1901946]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408