Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EQH37_RS06440 Genome accession   NZ_CP035243
Coordinates   1291041..1291778 (-) Length   245 a.a.
NCBI ID   WP_000782689.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901946     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1286041..1296778
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH37_RS06420 (EQH37_06775) msrB 1287455..1288393 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EQH37_RS06425 - 1288460..1288657 (-) 198 WP_025169195.1 hypothetical protein -
  EQH37_RS06430 (EQH37_06785) thrB 1288733..1289602 (-) 870 WP_000692438.1 homoserine kinase -
  EQH37_RS06435 (EQH37_06790) - 1289604..1290890 (-) 1287 WP_061389096.1 homoserine dehydrogenase -
  EQH37_RS06440 (EQH37_06795) mecA 1291041..1291778 (-) 738 WP_000782689.1 adaptor protein MecA Regulator
  EQH37_RS06445 (EQH37_06800) - 1291978..1293012 (-) 1035 WP_000461498.1 hypothetical protein -
  EQH37_RS06450 (EQH37_06805) - 1293041..1294474 (-) 1434 WP_001813454.1 O-antigen polysaccharide polymerase Wzy family protein -
  EQH37_RS06455 (EQH37_06810) - 1294490..1295476 (-) 987 WP_050233468.1 glycosyltransferase family 2 protein -
  EQH37_RS06460 (EQH37_06815) - 1295478..1296581 (-) 1104 WP_000225892.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28380.20 Da        Isoelectric Point: 4.0385

>NTDB_id=337208 EQH37_RS06440 WP_000782689.1 1291041..1291778(-) (mecA) [Streptococcus pneumoniae strain TVO_1901946]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFENLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=337208 EQH37_RS06440 WP_000782689.1 1291041..1291778(-) (mecA) [Streptococcus pneumoniae strain TVO_1901946]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAAACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.39

100

0.482
  mecA Streptococcus thermophilus LMG 18311

46.988

100

0.478
  mecA Streptococcus mutans UA159

47.755

100

0.478

Multiple sequence alignment