Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   EQH45_RS11000 Genome accession   NZ_CP035235
Coordinates   2146220..2147545 (-) Length   441 a.a.
NCBI ID   WP_001853914.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1902276     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2141220..2152545
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH45_RS11255 (EQH45_11510) - 2142909..2144558 (-) 1650 Protein_2149 YhgE/Pip family protein -
  EQH45_RS10980 (EQH45_11515) - 2144686..2145228 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  EQH45_RS10995 (EQH45_11530) comE 2145471..2146223 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  EQH45_RS11000 (EQH45_11535) comD/comD1 2146220..2147545 (-) 1326 WP_001853914.1 competence system sensor histidine kinase ComD Regulator
  EQH45_RS11005 (EQH45_11540) comC/comC1 2147566..2147691 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  EQH45_RS11015 (EQH45_11550) rlmH 2147974..2148453 (-) 480 WP_000695930.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  EQH45_RS11020 (EQH45_11555) htrA 2148636..2149817 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  EQH45_RS11025 (EQH45_11560) spo0J 2149875..2150633 (+) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51230.69 Da        Isoelectric Point: 6.9339

>NTDB_id=336713 EQH45_RS11000 WP_001853914.1 2146220..2147545(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1902276]
MDLFGFGTVIVHFLIISHNYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFSLGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=336713 EQH45_RS11000 WP_001853914.1 2146220..2147545(-) (comD/comD1) [Streptococcus pneumoniae strain TVO_1902276]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAACTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTTCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.413

100

0.984
  comD/comD1 Streptococcus pneumoniae D39

98.413

100

0.984
  comD/comD1 Streptococcus pneumoniae R6

98.413

100

0.984
  comD/comD2 Streptococcus pneumoniae TIGR4

96.145

100

0.961
  comD Streptococcus mitis SK321

92.29

100

0.923
  comD Streptococcus mitis NCTC 12261

86.168

100

0.862
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42

Multiple sequence alignment