Detailed information NTG0336712

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: EQH45_RS10995
• Genome accession: NZ_CP035235
• Coordinates: 2145471..2146223 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1902276
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2140471..2151223

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EQH45_RS11255 (EQH45_11510)	-	2142909..2144558 (-)	1650	Protein_2149	YhgE/Pip family protein	-
EQH45_RS10980 (EQH45_11515)	-	2144686..2145228 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
EQH45_RS10995 (EQH45_11530)	comE	2145471..2146223 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
EQH45_RS11000 (EQH45_11535)	comD/comD1	2146220..2147545 (-)	1326	WP_001853914.1	competence system sensor histidine kinase ComD	Regulator
EQH45_RS11005 (EQH45_11540)	comC/comC1	2147566..2147691 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
EQH45_RS11015 (EQH45_11550)	rlmH	2147974..2148453 (-)	480	WP_000695930.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
EQH45_RS11020 (EQH45_11555)	htrA	2148636..2149817 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
EQH45_RS11025 (EQH45_11560)	spo0J	2149875..2150633 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=336712 EQH45_RS10995 WP_000866065.1 2145471..2146223(-) (comE) [Streptococcus pneumoniae strain TVO_1902276]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=336712 EQH45_RS10995 WP_000866065.1 2145471..2146223(-) (comE) [Streptococcus pneumoniae strain TVO_1902276]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408