Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   EQH46_RS06375 Genome accession   NZ_CP035234
Coordinates   1270896..1271633 (-) Length   245 a.a.
NCBI ID   WP_000782665.1    Uniprot ID   A0A0B7LV94
Organism   Streptococcus pneumoniae strain TVO_1902277     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1265896..1276633
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH46_RS06360 (EQH46_06670) msrB 1267400..1268338 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  EQH46_RS06365 (EQH46_06675) thrB 1268588..1269457 (-) 870 WP_000692438.1 homoserine kinase -
  EQH46_RS06370 (EQH46_06680) - 1269459..1270745 (-) 1287 WP_000216385.1 homoserine dehydrogenase -
  EQH46_RS06375 (EQH46_06685) mecA 1270896..1271633 (-) 738 WP_000782665.1 adaptor protein MecA Regulator
  EQH46_RS06380 (EQH46_06690) - 1271775..1272809 (-) 1035 WP_000461502.1 hypothetical protein -
  EQH46_RS06385 (EQH46_06695) - 1272838..1274271 (-) 1434 WP_000565081.1 O-antigen polysaccharide polymerase Wzy family protein -
  EQH46_RS06390 (EQH46_06700) - 1274287..1275273 (-) 987 WP_000446966.1 glycosyltransferase family 2 protein -
  EQH46_RS06395 (EQH46_06705) - 1275275..1276378 (-) 1104 WP_000225894.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28377.18 Da        Isoelectric Point: 4.0236

>NTDB_id=336593 EQH46_RS06375 WP_000782665.1 1270896..1271633(-) (mecA) [Streptococcus pneumoniae strain TVO_1902277]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=336593 EQH46_RS06375 WP_000782665.1 1270896..1271633(-) (mecA) [Streptococcus pneumoniae strain TVO_1902277]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAACAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTTTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LV94

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

48.571

100

0.486

Multiple sequence alignment