Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SEQ_RS09455 Genome accession   NC_012471
Coordinates   1939826..1940590 (-) Length   254 a.a.
NCBI ID   WP_012680100.1    Uniprot ID   C0M8J4
Organism   Streptococcus equi subsp. equi 4047     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1934826..1945590
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SEQ_RS09435 (SEQ_1928) - 1935165..1936391 (-) 1227 WP_012680096.1 cysteine desulfurase -
  SEQ_RS09440 (SEQ_1929) sufD 1936418..1937680 (-) 1263 WP_012680097.1 Fe-S cluster assembly protein SufD -
  SEQ_RS09445 (SEQ_1930) sufC 1937771..1938541 (-) 771 WP_042357214.1 Fe-S cluster assembly ATPase SufC -
  SEQ_RS09450 (SEQ_1931) - 1938662..1939819 (-) 1158 WP_012680099.1 MraY family glycosyltransferase -
  SEQ_RS09455 (SEQ_1932) mecA 1939826..1940590 (-) 765 WP_012680100.1 adaptor protein MecA Regulator
  SEQ_RS09460 (SEQ_1933) - 1940710..1941549 (-) 840 WP_012680101.1 undecaprenyl-diphosphate phosphatase -
  SEQ_RS09465 (SEQ_1934) - 1941865..1943433 (+) 1569 WP_012516295.1 ABC transporter substrate-binding protein/permease -
  SEQ_RS09470 (SEQ_1935) - 1943426..1944166 (+) 741 WP_012680102.1 amino acid ABC transporter ATP-binding protein -
  SEQ_RS11630 (SEQ_1936) - 1944514..1944630 (+) 117 WP_012677375.1 putative metal homeostasis protein -

Sequence

Protein


Download         Length: 254 a.a.        Molecular weight: 29192.03 Da        Isoelectric Point: 4.2461

>NTDB_id=33548 SEQ_RS09455 WP_012680100.1 1939826..1940590(-) (mecA) [Streptococcus equi subsp. equi 4047]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYAVMDELGLPDNFKDSGMLSFRVTPRKDRLDVFVTKSDL
NKDLNFEDLADLGDISQMTPEDFFRSLEQSMREKGDVNAHEKLEKIEEIMEDVVDATLAEQADSKEAAELDEPTEPLDYV
HYVLDFASVRDAVCFAKVIDFPIEASELYKGPRHYHMTILLDVQNKPAYFANVMYARLIEHASPGTKTRAYLQEHGCQLI
FDGAVEELQKIRLG

Nucleotide


Download         Length: 765 bp        

>NTDB_id=33548 SEQ_RS09455 WP_012680100.1 1939826..1940590(-) (mecA) [Streptococcus equi subsp. equi 4047]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGGGGGATGGAGCT
CAAGGACTTCTTGATCCCTCAAGAAAAGACAGAGGAGTTCTTTTATGCTGTCATGGACGAGTTGGGCCTTCCGGACAATT
TTAAGGACAGTGGTATGCTTAGCTTTCGAGTGACTCCAAGAAAGGATCGCTTAGATGTTTTTGTGACCAAATCAGACCTC
AATAAGGACCTTAATTTTGAGGATTTGGCAGACCTAGGTGATATTTCTCAAATGACTCCAGAGGATTTTTTCAGAAGCTT
GGAGCAGTCTATGCGTGAAAAGGGTGATGTCAATGCCCATGAAAAGCTTGAAAAAATCGAGGAGATCATGGAGGACGTGG
TTGATGCTACCTTGGCTGAGCAAGCAGATAGTAAGGAAGCTGCTGAGCTTGATGAGCCGACAGAGCCACTTGATTATGTT
CACTATGTTCTTGATTTTGCTTCTGTTCGAGACGCTGTTTGCTTTGCTAAGGTGATTGATTTTCCGATCGAGGCTTCTGA
ATTGTATAAGGGTCCTCGTCATTATCACATGACGATTTTACTTGATGTGCAAAACAAGCCTGCCTACTTTGCCAACGTGA
TGTATGCCAGATTGATTGAGCATGCTAGTCCTGGAACAAAAACAAGAGCTTATTTGCAGGAGCATGGTTGTCAGCTCATT
TTTGATGGTGCTGTTGAGGAGCTGCAAAAAATCAGGTTGGGGTAG

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0M8J4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.347

98.819

0.626
  mecA Streptococcus thermophilus LMD-9

56.863

100

0.571
  mecA Streptococcus thermophilus LMG 18311

56.078

100

0.563
  mecA Streptococcus pneumoniae TIGR4

48.031

100

0.48
  mecA Streptococcus pneumoniae Rx1

47.638

100

0.476
  mecA Streptococcus pneumoniae D39

47.638

100

0.476
  mecA Streptococcus pneumoniae R6

47.638

100

0.476

Multiple sequence alignment