Detailed information NTG0331784

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: EHW89_RS04050
• Genome accession: NZ_CP034543
• Coordinates: 831933..834161 (+)
• Length: 742 a.a.
• NCBI ID: WP_126466819.1
• Uniprot ID: A0A3Q9F3B2
• Organism: Streptococcus periodonticum strain KCOM 2412
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 826933..839161

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EHW89_RS04025 (EHW89_04025)	rpmG	827787..827936 (+)	150	WP_003024746.1	50S ribosomal protein L33	-
EHW89_RS04030 (EHW89_04030)	secG	827976..828209 (+)	234	WP_003024744.1	preprotein translocase subunit SecG	-
EHW89_RS04035 (EHW89_04035)	rnr	828301..830634 (+)	2334	WP_126466815.1	ribonuclease R	-
EHW89_RS04040 (EHW89_04040)	smpB	830597..831064 (+)	468	WP_022526922.1	SsrA-binding protein SmpB	-
EHW89_RS04045 (EHW89_04045)	comEA/celA/cilE	831245..831949 (+)	705	WP_126466817.1	helix-hairpin-helix domain-containing protein	Machinery gene
EHW89_RS04050 (EHW89_04050)	comEC/celB	831933..834161 (+)	2229	WP_126466819.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EHW89_RS04055 (EHW89_04055)	-	834243..834614 (+)	372	WP_223350767.1	hypothetical protein	-
EHW89_RS09505	-	834614..834784 (+)	171	WP_226997586.1	hypothetical protein	-
EHW89_RS04060 (EHW89_04060)	-	835439..836425 (+)	987	WP_126466821.1	Gfo/Idh/MocA family protein	-
EHW89_RS04065 (EHW89_04065)	-	836447..837100 (+)	654	WP_126466823.1	uracil-DNA glycosylase	-
EHW89_RS04070 (EHW89_04070)	-	837137..837607 (+)	471	WP_003031692.1	8-oxo-dGTP diphosphatase	-
EHW89_RS04075 (EHW89_04075)	-	837620..838897 (+)	1278	WP_126466825.1	dihydroorotase	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 85089.93 Da
• Isoelectric Point: 10.0162

>NTDB_id=331784 EHW89_RS04050 WP_126466819.1 831933..834161(+) (comEC/celB) [Streptococcus periodonticum strain KCOM 2412]
MSQWIKRFPIKPIYIAFLLVWLYFAIYQSSWLAWLGFIFLGIRLFRFYSPKECFMTFMILSCFAGFFFVRREIAEQKTKV
EPSPIRQVAVLPDTIKVNGDSLSFRGKTNGQTYQVYYKLKSKEEQLAFQNLSSLVTLTVEGEFEIPEKKRNFDGFDYQSY
LKTQGIYRILKVDTILSSQDRISLHPLEWLSSWRRKALVFIKNHFPNPMSNYMTGLLFGALDTAFDEMSNLYSSLGIIHL
FALSGMQVGFFMEGFRKLLLRLGFTQEMVRKCQYPFSFFYAGMTGFSVSVVRSLIQKLLSQHGITKLDNFALTMMILSLI
MPSFLLSAGGVLSCAYAFVISVIDFEGLASWRKVVVESSVISLGVLPILIFYFGEFQPWSILLIFVFSLIFDAMMLPGLM
FIFLFSPLIKLTQVNFLFEGLENSIRWIASAFGKPIVFGQPSPLLLIIMLLVLAILYDVRKNKKWVIFLSLFLSLLFFVT
KFPLQNEITMVDVGQADSIFLRDWKGKNVLIDVGGREEIRTKEVWQKRAISSNAEKILIPYLKSRGVDTIDTLVLTNPNP
DYAGDVLEVAKKFAIKKIYISRSSLSNADFLKKLRETNTFIHVVKQGDKLPIFDHHLQVLSGASKNDHSIVLYGQFFRTR
FLFASDLKEEEEAKLMQHYPKLKTDVLKVGQHGAKSSSSSKFLQQIEPTVALISVGKNNQSKQPSQDTIERFAQLPAKLY
RTDEQGAVKFSGWTNWRLETVK

Nucleotide

• Length: 2229 bp

>NTDB_id=331784 EHW89_RS04050 WP_126466819.1 831933..834161(+) (comEC/celB) [Streptococcus periodonticum strain KCOM 2412]
ATGTCACAGTGGATTAAAAGATTTCCGATTAAGCCAATTTACATAGCTTTTTTGCTTGTCTGGTTATATTTTGCAATCTA
TCAAAGTAGCTGGTTAGCATGGCTTGGTTTTATCTTTCTAGGGATTCGTCTTTTTCGATTTTATTCACCGAAAGAATGTT
TCATGACCTTCATGATCCTCTCTTGTTTTGCTGGTTTTTTCTTTGTTCGTAGGGAGATAGCAGAGCAGAAGACGAAAGTA
GAACCTTCTCCTATAAGACAAGTGGCAGTTCTACCTGACACGATTAAGGTAAATGGAGATTCGCTTTCTTTCCGTGGTAA
AACAAATGGGCAGACTTATCAAGTTTACTACAAATTGAAATCAAAGGAAGAACAATTGGCTTTTCAAAATCTCTCTAGTT
TGGTTACATTGACAGTTGAGGGAGAATTTGAAATCCCTGAGAAGAAGCGTAATTTTGATGGTTTTGATTACCAATCTTAT
TTAAAAACGCAAGGGATTTATCGAATTTTAAAAGTAGATACCATTTTATCGAGCCAAGATAGAATCAGCTTGCACCCTTT
GGAGTGGCTCTCTAGCTGGCGAAGAAAGGCACTGGTATTTATCAAGAACCATTTTCCAAATCCGATGAGTAATTACATGA
CGGGGCTCTTATTTGGCGCCTTGGATACAGCCTTTGACGAAATGAGCAATCTTTATTCTAGCTTGGGAATTATTCATTTA
TTTGCGCTGTCTGGCATGCAAGTTGGCTTTTTTATGGAGGGATTTCGCAAGTTACTGTTAAGGCTGGGGTTCACACAAGA
AATGGTTCGTAAATGCCAATATCCATTTTCTTTCTTTTATGCGGGAATGACTGGATTTTCAGTATCCGTTGTACGGAGCT
TAATTCAGAAATTATTATCGCAACATGGTATCACTAAGTTAGATAATTTTGCTTTAACGATGATGATATTGTCCTTGATT
ATGCCGTCCTTTCTTTTGTCGGCAGGAGGAGTTCTCTCCTGTGCTTATGCTTTTGTCATTAGTGTGATAGATTTTGAAGG
TCTGGCTTCTTGGCGAAAAGTTGTTGTAGAGAGTAGCGTTATTTCACTTGGTGTTTTACCAATTCTAATCTTTTACTTTG
GTGAATTTCAACCTTGGTCTATTTTGTTGATATTTGTTTTTTCACTGATTTTTGATGCAATGATGCTACCAGGCTTGATG
TTTATTTTTCTTTTTTCGCCTTTGATAAAGCTGACTCAAGTCAATTTTCTATTTGAAGGGTTAGAAAATAGTATTCGTTG
GATAGCAAGTGCCTTTGGTAAACCAATCGTTTTTGGGCAGCCCAGCCCGCTTTTGCTGATTATTATGCTGCTTGTATTGG
CTATTTTGTATGATGTTAGAAAAAATAAAAAATGGGTAATATTTCTTAGTCTGTTTCTTTCATTACTCTTTTTTGTAACT
AAATTTCCTTTGCAAAACGAGATCACAATGGTGGATGTCGGGCAAGCAGATAGTATTTTTCTGAGAGACTGGAAAGGAAA
AAATGTATTGATTGATGTTGGCGGACGTGAGGAAATTAGAACAAAAGAAGTTTGGCAAAAACGAGCAATTAGCTCAAATG
CAGAAAAAATTTTGATTCCTTATCTAAAAAGTCGTGGCGTAGATACGATTGATACTTTAGTCTTAACAAATCCTAATCCA
GATTATGCAGGAGATGTATTAGAAGTTGCTAAAAAGTTTGCAATAAAGAAAATTTATATTTCCAGAAGTAGTCTAAGCAA
TGCAGATTTCCTAAAGAAATTAAGGGAGACAAATACATTCATTCATGTCGTAAAACAAGGTGACAAACTTCCTATTTTTG
ATCATCATTTGCAAGTTCTTTCGGGTGCTAGCAAGAACGACCATTCGATTGTTTTATATGGTCAGTTTTTCCGTACAAGA
TTTTTATTTGCAAGCGATTTGAAAGAAGAAGAGGAAGCAAAGTTGATGCAACATTATCCAAAGTTGAAAACAGATGTCTT
GAAAGTCGGGCAACATGGAGCTAAAAGTTCATCAAGTTCAAAGTTTTTGCAACAAATAGAACCAACGGTTGCGCTCATTT
CTGTCGGGAAAAATAATCAATCTAAGCAACCTAGTCAAGATACAATAGAGCGATTTGCACAATTGCCTGCTAAACTCTAT
CGGACAGATGAACAAGGGGCAGTTAAATTTTCAGGGTGGACAAACTGGCGATTAGAAACGGTCAAGTAA

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-460)

• Domain of unknown function (DUF4131) (DUF4131) (30-175)

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-695)

3D structure

• AlphaFold DB: A0A3Q9F3B2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	54.618	100	0.55
comEC/celB	Streptococcus mitis NCTC 12261	54.155	100	0.544
comEC/celB	Streptococcus pneumoniae TIGR4	53.681	100	0.54
comEC/celB	Streptococcus pneumoniae Rx1	52.878	100	0.532
comEC/celB	Streptococcus pneumoniae D39	52.878	100	0.532
comEC/celB	Streptococcus pneumoniae R6	52.878	100	0.532
comEC	Lactococcus lactis subsp. cremoris KW2	46.98	100	0.472