Detailed information NTG0331343

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: EJF26_RS03810
• Genome accession: NZ_CP034442
• Coordinates: 736516..738756 (-)
• Length: 746 a.a.
• NCBI ID: WP_000942440.1
• Uniprot ID: F9P185
• Organism: Streptococcus oralis subsp. dentisani strain F0392
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 731516..743756

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EJF26_RS03775	-	732419..732799 (-)	381	WP_000157143.1	VOC family protein	-
EJF26_RS03780	rplT	732858..733217 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
EJF26_RS03785	rpmI	733269..733469 (-)	201	WP_001125942.1	50S ribosomal protein L35	-
EJF26_RS03790	infC	733502..734032 (-)	531	WP_000848184.1	translation initiation factor IF-3	-
EJF26_RS03795	-	734336..735520 (-)	1185	WP_000652065.1	ABC transporter permease	-
EJF26_RS03800	-	735517..736110 (-)	594	WP_000956988.1	ATP-binding cassette domain-containing protein	-
EJF26_RS03810	comEC/celB	736516..738756 (-)	2241	WP_000942440.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EJF26_RS03815	comEA/celA/cilE	738740..739387 (-)	648	WP_000452007.1	helix-hairpin-helix domain-containing protein	Machinery gene
EJF26_RS03820	-	739454..740023 (-)	570	WP_000443761.1	GNAT family N-acetyltransferase	-
EJF26_RS03830	ald	740200..741312 (+)	1113	WP_000904717.1	alanine dehydrogenase	-
EJF26_RS03835	-	741375..742361 (-)	987	WP_000658171.1	PhoH family protein	-
EJF26_RS03840	-	742442..742657 (-)	216	WP_001232085.1	YozE family protein	-
EJF26_RS03845	-	742654..743259 (-)	606	WP_029745494.1	GrpB family protein	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84487.98 Da
• Isoelectric Point: 9.5153

>NTDB_id=331343 EJF26_RS03810 WP_000942440.1 736516..738756(-) (comEC/celB) [Streptococcus oralis subsp. dentisani strain F0392]
MLQWIKSLPIPLIYLGFLLLWLYYAIFSVSYLALLGFVFLLLCLFHQFPWKSAGKVLAICGAFGFWFLFQAWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKADGRTFQVYYKLQSEEEKEQFQALTDIYEIELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLTIKRIKSLKQVRSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDAFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSTSVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLVISLGILPILSFYFAEFQPWSILLTFVFPFLFDLIFLPLLSI
LFAFSFVYPAVQFNLIFEWLEGIIRLVSQMASRPLVFGQPNAWLLILLLVSLALVYDMRKNIKRLAGFSLFIVGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESDKKIESWQKKVTTSNAQKTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVTKAFHVGEILVSKGSLTQKEFVAELQATKIKVRSVTAGENLPIFGSQLEVLSPREIGEADADDSLVLHGKL
LDKHFLFTGNLKGKGEKELLKQYPDIEVDVLKAGQHGAKTSSNPVFLEKLKPEITLISVGKNSRAKLPHQETLTRLESIK
SKIYRTDQQGAIRFKGWNSWRMESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=331343 EJF26_RS03810 WP_000942440.1 736516..738756(-) (comEC/celB) [Streptococcus oralis subsp. dentisani strain F0392]
ATGTTACAGTGGATTAAGAGTCTTCCTATCCCCTTAATCTATCTGGGTTTTCTATTACTTTGGCTTTACTATGCCATTTT
CTCAGTATCTTATCTTGCTTTACTAGGCTTTGTTTTTTTGCTGCTCTGTCTCTTTCATCAATTTCCTTGGAAATCTGCAG
GCAAAGTTTTAGCGATTTGTGGAGCCTTTGGCTTTTGGTTTCTGTTTCAAGCTTGGCAGCAGAGTCAAGCTAGTCAAAAC
CTAGCGGATTCTGTTGAGAGGGTACGAATTTTGCCAGATACCATCAAGGTCAATGGAGATAGTCTGTCCTTTAGGGGCAA
GGCCGACGGCCGTACTTTCCAAGTCTACTATAAACTCCAGTCCGAGGAGGAGAAAGAGCAATTTCAGGCCTTGACAGATA
TTTATGAGATAGAACTAGAAGGAAAACTGTCCGAGCCAGAAGGCCAGAGAAATTTTGGTGGATTTGACTACCAAGCCTAT
CTGAAGACTCAGGGGATTTACCAGACACTAACTATCAAGAGAATCAAGTCACTTAAACAGGTTCGCAGTTGGGATATAGG
AGAAAATCTGTCCAGTTTACGTCGAAAGGCTGTAGTTTGGATCAAGACGCACTTTCCAGATCCTATGCGGAACTACATGA
CGGGGCTTTTGCTAGGACATCTGGATACGGACTTTGAGGAGATGAATGAGCTTTATTCTAGTCTAGGGATTATCCATCTC
TTTGCCTTGTCTGGTATGCAGGTGGGCTTTTTCATGGATGCCTTTAAGAAACTCCTATTACGATTGGGCTTGACTCAAGA
AAAGTTGAAGTGGCTAACTTATCCTTTTTCCCTTATCTATGCAGGTCTGACAGGATTCTCGACTTCGGTCATTCGTAGTC
TCTTGCAAAAGTTACTAGCCCAACATGGTGTTAAGGGCCTGGATAATTTCGCCTTGACGGTTCTTGTCCTCTTTATCATC
ATGCCCAACTTTTTCCTGACGGCAGGAGGTGTCTTGTCCTGTGCCTACGCTTTTATCTTGACTATGACAAGTAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCCAGAGAAAGTCTAGTCATTTCCTTAGGAATATTGCCCATTCTATCTTTCTATTTTGCAG
AATTTCAGCCTTGGTCTATCCTTTTGACCTTTGTCTTTCCCTTTCTTTTTGACTTGATTTTCTTACCACTCTTATCTATC
TTGTTTGCCTTTTCTTTTGTCTATCCTGCCGTTCAATTTAACCTTATCTTTGAATGGTTGGAGGGCATAATTCGCTTGGT
TTCGCAGATGGCAAGCAGGCCTTTGGTCTTTGGACAACCCAATGCATGGCTATTGATTCTTCTCTTAGTTTCATTAGCCT
TGGTCTATGATATGAGAAAAAATATCAAAAGACTAGCAGGGTTTAGTCTCTTTATCGTGGGGCTCTTTTTCTTGACCAAA
TATCCACTGGAAAATGAAATCACTATGCTGGATGTAGGGCAGGGGGAAAGTATTTTTCTACGGGATGTGACTGGTAAAAC
CATCCTCATAGATGTGGGAGGCAAGGCAGAATCTGATAAGAAAATCGAATCTTGGCAGAAGAAGGTAACTACTAGCAATG
CCCAGAAAACCTTGATTCCTTATCTTAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTGATTTTGACCAACACAGACAAG
GAACATGTTGGAGATTTGCTGGAGGTGACCAAGGCTTTCCATGTCGGGGAGATTTTAGTATCAAAAGGAAGTCTGACACA
GAAGGAATTTGTAGCAGAACTACAAGCGACTAAAATCAAGGTACGCAGTGTGACAGCAGGGGAGAACTTGCCGATTTTTG
GCAGTCAGTTAGAAGTATTATCTCCAAGGGAAATTGGAGAAGCTGATGCCGATGATTCCTTGGTTCTTCATGGAAAACTT
TTGGATAAGCACTTTCTCTTTACTGGAAACTTGAAAGGGAAGGGAGAGAAAGAACTTTTAAAGCAATACCCTGACATAGA
AGTGGATGTCTTGAAAGCAGGCCAGCATGGTGCTAAAACTTCATCAAATCCAGTTTTCCTAGAAAAACTCAAACCAGAGA
TCACTCTTATTTCAGTGGGTAAGAACAGTCGTGCCAAGCTCCCCCATCAGGAAACCTTGACACGATTGGAATCCATCAAG
AGTAAGATTTACCGAACCGATCAGCAAGGAGCCATTCGCTTTAAAGGATGGAATAGTTGGCGAATGGAAAGTGTTCGTTA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-662)

• Domain of unknown function (DUF4131) (DUF4131) (27-176)

• Competence protein (Competence) (216-458)

3D structure

• AlphaFold DB: F9P185

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	88.606	100	0.886
comEC/celB	Streptococcus mitis NCTC 12261	88.188	99.866	0.881
comEC/celB	Streptococcus pneumoniae TIGR4	86.595	100	0.866
comEC/celB	Streptococcus pneumoniae Rx1	86.059	100	0.861
comEC/celB	Streptococcus pneumoniae D39	86.059	100	0.861
comEC/celB	Streptococcus pneumoniae R6	86.059	100	0.861
comEC	Lactococcus lactis subsp. cremoris KW2	45.418	99.464	0.452