Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   EJF26_RS03720 Genome accession   NZ_CP034442
Coordinates   721848..722522 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis subsp. dentisani strain F0392     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 716848..727522
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EJF26_RS03695 - 716982..717911 (-) 930 WP_000411185.1 peptidase U32 family protein -
  EJF26_RS03700 - 718037..718717 (-) 681 WP_000125736.1 ABC transporter ATP-binding protein -
  EJF26_RS03705 - 718731..719786 (-) 1056 WP_000280274.1 ABC transporter permease -
  EJF26_RS03710 - 720172..720456 (+) 285 WP_001111509.1 DUF3270 domain-containing protein -
  EJF26_RS03715 ciaH 720521..721858 (-) 1338 WP_000482352.1 cell wall metabolism sensor histidine kinase WalK Regulator
  EJF26_RS03720 ciaR 721848..722522 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  EJF26_RS03725 - 722632..725178 (-) 2547 WP_001149137.1 M1 family metallopeptidase -
  EJF26_RS03730 - 725301..725741 (-) 441 WP_000188803.1 ASCH domain-containing protein -
  EJF26_RS03735 - 725766..726362 (-) 597 WP_001101063.1 DUF6707 family protein -
  EJF26_RS03740 - 726396..726755 (-) 360 WP_000800853.1 hypothetical protein -
  EJF26_RS03745 - 726733..727233 (-) 501 WP_000403619.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=331342 EJF26_RS03720 WP_000590630.1 721848..722522(-) (ciaR) [Streptococcus oralis subsp. dentisani strain F0392]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=331342 EJF26_RS03720 WP_000590630.1 721848..722522(-) (ciaR) [Streptococcus oralis subsp. dentisani strain F0392]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCTGATGT
CATGCAGGTCTTTGATGGTGAAGAAGGACTTTACGAAGCTGAGAGTGGCGTTTATGACTTGATTCTGCTTGACCTCATGT
TGCCTGAAAAAAATGGCTTCCAAGTTTTGAAAGAATTGCGTGAAAAAGGAATTACAACCCCTGTCCTTATCATGACTGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCAGATGATTATCTGACCAAGCCTTTCTACCTTGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAATACCTTGACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTTGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACTAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAGAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment