Detailed information NTG0330307

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: EFD74_RS09720
• Genome accession: NZ_CP034259
• Coordinates: 1981057..1982100 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain P1D12C1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1976057..1987100

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EFD74_RS09690 (EFD74_10120)	-	1976478..1977734 (-)	1257	WP_001795108.1	aminopeptidase	-
EFD74_RS09695 (EFD74_10125)	-	1977737..1977937 (-)	201	WP_000180460.1	DUF1128 family protein	-
EFD74_RS09700 (EFD74_10130)	-	1978084..1978548 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
EFD74_RS09705 (EFD74_10135)	-	1978555..1978830 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
EFD74_RS09710 (EFD74_10140)	-	1979108..1980325 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
EFD74_RS09715 (EFD74_10145)	vraR	1980438..1981067 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
EFD74_RS09720 (EFD74_10150)	vraS	1981057..1982100 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
EFD74_RS09725 (EFD74_10155)	liaF	1982097..1982798 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
EFD74_RS09730 (EFD74_10160)	-	1982813..1983199 (-)	387	WP_001110179.1	hypothetical protein	-
EFD74_RS09735 (EFD74_10165)	map	1983416..1984174 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
EFD74_RS09740 (EFD74_10175)	-	1984705..1985691 (+)	987	WP_000999717.1	FUSC family protein	-
EFD74_RS09745 (EFD74_10185)	-	1986122..1986535 (-)	414	WP_001557448.1	hypothetical protein	-
EFD74_RS09750 (EFD74_10190)	-	1986564..1986674 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=330307 EFD74_RS09720 WP_001017131.1 1981057..1982100(-) (vraS) [Staphylococcus aureus strain P1D12C1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=330307 EFD74_RS09720 WP_001017131.1 1981057..1982100(-) (vraS) [Staphylococcus aureus strain P1D12C1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1