Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   SUB_RS06960 Genome accession   NC_012004
Coordinates   1380493..1382379 (-) Length   628 a.a.
NCBI ID   WP_015911705.1    Uniprot ID   -
Organism   Streptococcus uberis 0140J     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 1375493..1387379
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SUB_RS06935 (SUB1380) - 1376255..1376611 (-) 357 WP_015911700.1 S1 RNA-binding domain-containing protein -
  SUB_RS06940 (SUB1381) - 1376611..1378011 (-) 1401 WP_037593423.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  SUB_RS06945 (SUB1382) - 1378045..1378686 (-) 642 WP_015911702.1 response regulator transcription factor -
  SUB_RS06950 (SUB1383) - 1378679..1379683 (-) 1005 WP_015911703.1 sensor histidine kinase -
  SUB_RS06955 (SUB1384) liaF 1379680..1380375 (-) 696 WP_015911704.1 cell wall-active antibiotics response protein LiaF -
  SUB_RS06960 (SUB1385) pknB 1380493..1382379 (-) 1887 WP_015911705.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SUB_RS06965 (SUB1386) - 1382376..1383116 (-) 741 WP_015911706.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  SUB_RS06970 (SUB1387) rsmB 1383154..1384476 (-) 1323 WP_015911707.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  SUB_RS06975 (SUB1388) fmt 1384466..1385401 (-) 936 WP_015911708.1 methionyl-tRNA formyltransferase -

Sequence

Protein


Download         Length: 628 a.a.        Molecular weight: 68248.36 Da        Isoelectric Point: 8.9122

>NTDB_id=32937 SUB_RS06960 WP_015911705.1 1380493..1382379(-) (pknB) [Streptococcus uberis 0140J]
MIQIGKLFAGRYRILKSIGRGGMADVYLANDLILDNEDVAIKVLRTNYQTDQVAVARFQREARAMAELNHPNIVAIRDIG
EEDGQQFLVMEYVDGADLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQKGIVHRDLKPQNILLTKSGVVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIMLYEMLTGHIPYDGDSAVTIALQHFQKPLPSILDENKMVP
QALENVVIKATAKKLSDRYASTFDMSRDLMTALSYNRSREKKLVFEDGDSTKPLPKVSPTPNVTPKSSPTVSATKANEPA
KQDYLQKPQKERKRGRFLGTLFKILFALFVVGVAIFTFLILTKPSTVKVPNLNGSTLSVAKAELKTMGFKVGDIKKIESG
TVAVGHVVKTDPSAGTAKREGATIDIFVSSGKKGFVMEDYTGQNYQDVISNLMTTYGVSRSKIKIKRINTNDYQADTVIS
QTPDKGEKFNPDGKSKITLSVASSGTVTMPDLTGYTYQEALNELTALGINTNRIKTYYTNGSSGEKKSMIVSEQTPYAYS
SISLSDSSEISLGLYAATETSNSSTPSSSSEVSSSSSSSTYDPGISSETTTSSSSSSTNAGLDPNNNP

Nucleotide


Download         Length: 1887 bp        

>NTDB_id=32937 SUB_RS06960 WP_015911705.1 1380493..1382379(-) (pknB) [Streptococcus uberis 0140J]
ATGATACAGATTGGCAAATTATTTGCTGGTCGTTATCGCATCTTAAAATCAATTGGCCGCGGTGGTATGGCGGATGTTTA
TTTAGCAAATGACTTGATATTAGATAATGAGGACGTAGCTATTAAGGTATTACGTACAAATTATCAAACAGATCAGGTTG
CAGTTGCACGTTTTCAACGAGAAGCGCGTGCGATGGCAGAATTAAATCATCCGAACATTGTAGCCATACGAGATATAGGT
GAAGAAGACGGACAGCAGTTTTTAGTAATGGAATACGTCGATGGTGCAGACTTGAAAAAATACATTCAAGATCATGCTCC
ACTGTCTAACAACGAAGTTGTTAGGATTATGGAGGAAGTTCTCTCTGCAATGACACTTGCTCACCAAAAGGGCATTGTTC
ATAGGGACTTAAAACCTCAAAATATTTTATTAACCAAATCTGGAGTCGTTAAAGTAACTGATTTTGGTATAGCTGTTGCA
TTTGCTGAAACGAGTTTAACCCAAACAAACTCCATGTTAGGAAGTGTGCATTATTTATCTCCAGAACAAGCTCGTGGCTC
AAAAGCGACTATTCAGAGCGATATATATGCAATGGGTATCATGCTTTATGAAATGTTGACTGGACATATTCCATATGATG
GAGATAGTGCAGTTACCATTGCTTTACAACATTTCCAAAAACCATTACCATCTATTTTAGATGAAAATAAAATGGTGCCA
CAAGCTTTGGAAAATGTGGTCATAAAAGCTACAGCTAAGAAGCTAAGTGATCGCTATGCTTCGACATTTGACATGAGCAG
GGATTTAATGACGGCTCTAAGCTATAATAGAAGCCGTGAGAAAAAATTAGTGTTTGAGGATGGCGACAGTACAAAGCCAT
TACCAAAAGTTTCTCCAACACCAAATGTAACCCCTAAATCATCTCCAACAGTTTCAGCAACTAAGGCAAATGAGCCTGCA
AAACAAGACTACTTGCAAAAACCACAAAAAGAGAGAAAACGAGGTCGTTTTTTAGGCACTTTATTCAAAATTCTCTTTGC
CCTATTTGTCGTAGGTGTGGCAATCTTTACCTTCCTTATTTTGACGAAACCATCAACGGTCAAAGTTCCTAATTTAAATG
GTTCAACTTTATCTGTCGCTAAAGCTGAATTGAAAACAATGGGATTTAAAGTTGGAGATATCAAAAAAATAGAAAGTGGA
ACTGTTGCGGTAGGTCATGTTGTTAAAACAGATCCTAGTGCTGGTACAGCAAAACGTGAAGGAGCCACTATTGATATATT
TGTATCATCTGGGAAAAAAGGTTTTGTCATGGAAGATTACACAGGACAAAATTACCAAGATGTTATTTCTAATCTGATGA
CTACTTATGGTGTTTCTCGTTCTAAAATCAAAATTAAACGAATCAACACAAATGACTATCAAGCAGATACAGTTATTAGC
CAAACGCCGGATAAAGGTGAAAAATTCAATCCGGATGGTAAGTCAAAAATTACCTTAAGTGTGGCATCAAGTGGAACTGT
TACAATGCCAGATTTAACAGGATATACTTACCAAGAAGCATTAAACGAATTGACTGCTTTAGGCATTAACACAAACCGGA
TCAAGACTTACTATACTAATGGTTCAAGTGGTGAAAAGAAATCCATGATTGTCTCAGAGCAAACCCCTTACGCTTATTCA
AGCATTTCTCTTTCTGATTCTAGTGAAATTAGTTTAGGATTATATGCCGCTACAGAAACGTCGAACAGCTCAACACCATC
AAGTTCAAGTGAAGTTTCCTCTTCTAGTAGTTCATCGACATATGATCCAGGAATTTCTTCAGAAACAACAACATCAAGTT
CTTCTTCTTCGACAAATGCGGGACTTGATCCAAATAACAATCCATAA

Domains

Predicted by InterproScan.

Protein kinase domain (Pkinase)

(12-253)

PASTA domain (PASTA)

(367-429)

PASTA domain (PASTA)

(436-502)

PASTA domain (PASTA)

(507-572)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

65.753

92.994

0.611
  stkP/pknB Streptococcus salivarius strain HSISS4

62.566

90.605

0.567
  stkP Streptococcus pneumoniae TIGR4

53.589

95.382

0.511
  stkP Streptococcus pneumoniae D39

53.422

95.382

0.51
  stkP Streptococcus pneumoniae R6

53.422

95.382

0.51
  stkP Streptococcus pneumoniae Rx1

53.255

95.382

0.508

Multiple sequence alignment