Detailed information NTG0328847

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: FOY97_RS12530
• Genome accession: NZ_CP041774
• Coordinates: 2567163..2567834 (+)
• Length: 223 a.a.
• NCBI ID: WP_003090494.1
• Uniprot ID: A0A0H2ZC88
• Organism: Pseudomonas aeruginosa strain 60503
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2562163..2572834

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOY97_RS12495 (FOY97_12495)	ppyR	2562636..2562893 (+)	258	WP_003090502.1	psl/pyoverdine operon transcriptional regulator PpyR	-
FOY97_RS12500 (FOY97_12500)	-	2562880..2564073 (+)	1194	WP_003131074.1	NnrS family protein	-
FOY97_RS12505 (FOY97_12505)	-	2564074..2564340 (-)	267	WP_003090500.1	DUF5329 domain-containing protein	-
FOY97_RS12510 (FOY97_12510)	-	2564324..2565217 (-)	894	WP_033939019.1	hypothetical protein	-
FOY97_RS12515 (FOY97_12515)	-	2565244..2566326 (-)	1083	WP_003113385.1	hypothetical protein	-
FOY97_RS12520 (FOY97_12520)	-	2566541..2566849 (+)	309	WP_003090497.1	PepSY domain-containing protein	-
FOY97_RS12525 (FOY97_12525)	-	2566849..2567163 (+)	315	WP_003131079.1	PepSY domain-containing protein	-
FOY97_RS12530 (FOY97_12530)	ciaR	2567163..2567834 (+)	672	WP_003090494.1	two-component system response regulator CarR	Regulator
FOY97_RS12535 (FOY97_12535)	carS	2567831..2569168 (+)	1338	WP_033939020.1	two-component system sensor histidine kinase CarS	-
FOY97_RS12540 (FOY97_12540)	-	2569259..2569567 (+)	309	WP_003097699.1	hypothetical protein	-
FOY97_RS12545 (FOY97_12545)	-	2569572..2571716 (-)	2145	WP_019485831.1	methyl-accepting chemotaxis protein	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 24729.20 Da
• Isoelectric Point: 5.8445

>NTDB_id=328847 FOY97_RS12530 WP_003090494.1 2567163..2567834(+) (ciaR) [Pseudomonas aeruginosa strain 60503]
MRLLLVEDHVPLADELMASLTRQGYAVDWLADGRDAAVQGASEPYDLIILDLGLPGRPGLEILQEWRGLGLATPVLILTA
RGSWAERIDGLKAGADDYLTKPFHPEELALRIQALLRRAHGLANQSQLEAAGLRLDEQRQCVCLNGADVDLTAAEFRLLR
YFMLHPGQVLSKGHLAEHLYDGETERDSNVIEVHVNHLRRKLGREVIETRRGQGYRYAGVAAG

Nucleotide

• Length: 672 bp

>NTDB_id=328847 FOY97_RS12530 WP_003090494.1 2567163..2567834(+) (ciaR) [Pseudomonas aeruginosa strain 60503]
ATGCGGTTGCTGCTGGTTGAGGATCACGTTCCCCTGGCCGACGAACTGATGGCCAGCCTGACCCGCCAGGGCTACGCGGT
GGACTGGCTGGCCGACGGCCGCGACGCGGCGGTGCAGGGCGCCAGCGAGCCCTACGACCTGATCATCCTCGACCTCGGCC
TGCCCGGGCGCCCCGGCCTGGAGATACTCCAGGAGTGGCGTGGGCTGGGACTCGCGACTCCGGTGCTGATCCTCACCGCG
CGCGGTTCCTGGGCCGAACGCATCGATGGCCTCAAGGCCGGTGCCGACGACTACCTGACCAAGCCGTTCCATCCGGAAGA
GTTGGCCTTGCGCATCCAGGCCCTGTTGCGCCGCGCCCATGGGCTGGCCAACCAGAGCCAGCTGGAGGCCGCTGGGCTGC
GCCTGGACGAGCAGCGCCAGTGCGTGTGCCTGAACGGCGCCGACGTCGACCTGACCGCCGCCGAATTCCGCCTGCTGCGC
TATTTCATGCTGCACCCCGGCCAGGTCCTGTCCAAGGGGCACCTGGCCGAGCATCTGTACGACGGCGAGACCGAACGCGA
TTCCAACGTCATCGAGGTCCACGTCAACCACCTGCGGCGCAAGCTCGGCCGCGAGGTGATCGAGACCCGCCGTGGCCAGG
GTTACCGCTACGCCGGGGTGGCCGCCGGATGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-216)

3D structure

• AlphaFold DB: A0A0H2ZC88

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	37.727	98.655	0.372
ciaR	Streptococcus pneumoniae Rx1	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae D39	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae R6	37.273	98.655	0.368
ciaR	Streptococcus pneumoniae TIGR4	37.273	98.655	0.368
micA	Streptococcus pneumoniae Cp1015	35.683	100	0.363
vicR	Streptococcus mutans UA159	35.526	100	0.363