Detailed information NTG0326037

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EGX80_RS05295
• Genome accession: NZ_CP033815
• Coordinates: 992500..993411 (+)
• Length: 303 a.a.
• NCBI ID: WP_011054099.1
• Uniprot ID: A0A5S4TJF2
• Organism: Streptococcus pyogenes strain FDAARGOS_514
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 987500..998411

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EGX80_RS05275 (EGX80_05285)	purE	987796..988287 (+)	492	WP_030127619.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EGX80_RS05280 (EGX80_05290)	purK	988274..989347 (+)	1074	WP_032461293.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EGX80_RS05285 (EGX80_05295)	-	989368..990708 (+)	1341	WP_002986685.1	hypothetical protein	-
EGX80_RS05290 (EGX80_05300)	purB	991077..992369 (+)	1293	WP_011054098.1	adenylosuccinate lyase	-
EGX80_RS05295 (EGX80_05305)	comR	992500..993411 (+)	912	WP_011054099.1	XRE family transcriptional regulator	Regulator
EGX80_RS10135	comS	993502..993600 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
EGX80_RS05300 (EGX80_05310)	ruvB	993631..994629 (+)	999	WP_011054100.1	Holliday junction branch migration DNA helicase RuvB	-
EGX80_RS05305 (EGX80_05315)	-	994767..995204 (+)	438	WP_002994668.1	low molecular weight phosphotyrosine protein phosphatase	-
EGX80_RS05310 (EGX80_05320)	-	995227..995628 (+)	402	WP_011017240.1	MORN repeat-containing protein	-
EGX80_RS05315 (EGX80_05325)	-	995625..997400 (+)	1776	WP_011054101.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35896.55 Da
• Isoelectric Point: 4.9324

>NTDB_id=326037 EGX80_RS05295 WP_011054099.1 992500..993411(+) (comR) [Streptococcus pyogenes strain FDAARGOS_514]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGHLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=326037 EGX80_RS05295 WP_011054099.1 992500..993411(+) (comR) [Streptococcus pyogenes strain FDAARGOS_514]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCATCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

3D structure

• AlphaFold DB: A0A5S4TJF2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	100	100	1
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.157	98.68	0.465
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366